Dimeric indole alkaloid purification process

Details Dimeric indole alkaloid purification process Dimeric indole alkaloid purification process

1973-10-24

1976-01-13

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21500

Patent

active

039324176

ABSTRACT:
Dimeric indole alkolids-vinblastine, des-N-methyl-vinblastine and vincristine-are purified by extracting leaves of Vinca rosea with acid, neutralizing the acidic solution, extracting the dimeric alkaloids into an aromatic solvent, optionally subjecting the extracted alkaloids to gel exclusion chromatography, precipitating the dimeric alkaloids as sulfate salts and finally separating the dimeric alkaloids by high-pressure chromatography.

REFERENCES:
patent: 3097137 (1963-07-01), Beer et al.
patent: 3205220 (1965-09-01), Svoboda et al.
patent: 3225030 (1965-12-01), Svoboda
Stahl et al., Chemical Abstracts, 1971, Vol. 75, abst. 29733a.

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