Dimeric epipodophyllotoxin glucoside derivatives

Details Dimeric epipodophyllotoxin glucoside derivatives Dimeric epipodophyllotoxin glucoside derivatives

1989-05-19

1990-10-23

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 173, 536 174, 536 181, 536 182, 536 175, 514 27, C07H 1524, C07H 1520, C07H 1526

Patent

active

049653482

ABSTRACT:
The present invention provides novel dimers of epipodophyllotoxin glucosides wherein the two units are connected via a diacyl linker. These compounds have useful property as tumor inhibiting agents.

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Levy, R. K. et al., "Antitumor Agents LXII: Synthesis and Biological Evaluation of Podophyllotoxin Esters and Related Derivatives", J. Pharm. Sci., 1983, 72(10):1158-1161.
Wakelin, L. P. G.; "Polyfunctional DNA Intercalating Agents", Medicinal Res. Rev., 1986, 6(3):275-340.

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