Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-09-29
1984-08-28
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
044683839
ABSTRACT:
The compounds of the invention are symmetrical dimers of enkephalin polypeptides comprising enkephalin polypeptide monomers linked at the C-termini thereof with a difunctional amino bridging group. The compounds are useful as investigative tools for probing the opiate receptor membranes, particularly as radiolabelled ligands for exploring the delta opiate receptor, and also have particular use as narcotic and/or analgesic agents.
REFERENCES:
patent: 4178284 (1979-12-01), Sarantakis
patent: 4198398 (1980-04-01), Hudson
Y. Shimohigashi, T. Costa, S. Matsuura, H. C. Chen, D. Rodbard "Dimeric enkephalins display enhanced affinity and selectivity for the delta opiate receptor", Mol. Pharm. 21: 558-563 (1982).
Y. Shimohigashi, T. Costa, S. Matsuura, H. C. Chen, D. Rodbard "Peptides-Synthesis-Structure-Function", Proc. Seventh American Peptide Symposium; published Nov. 1981 by the Pierce Chemical Co.
Chen Hao-Chia
Costa Tommaso
Rodbard David
Shimohigashi Y.
Phillips Delbert R.
The United States of America as represented by the Secretary of
LandOfFree
Dimeric enkephalins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dimeric enkephalins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dimeric enkephalins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-877083