Dimeric compounds and their use as anti-viral agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S424000, C549S425000

Reexamination Certificate

active

10494243

ABSTRACT:
The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to 3; and Y is hydrogen or an aromatic substituent, or a pharmaceutically acceptable derivative thereof; methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection

REFERENCES:
patent: 6548476 (2003-04-01), Wu et al.
patent: WO 00/55149 (2000-09-01), None
patent: WO 02/20514 (2002-03-01), None
McDonald, SJF et al ‘Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influena neuraminidase including H5n1 avian’ CA 142:423048 (2005).
Fleming, DM ‘Managing influenza: amantadine, rimantadine and beyond’ PMID: 11351773 (2001).

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