Dimer of the precursor of HIV-2 envelope glycoprotein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 5, 530350, 930221, C07K 1504, C07K 1514

Patent

active

053129024

ABSTRACT:
Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 mature virions. The gp300, which is a dimeric form of gp140, the precursor of HIV-2 envelope glycoprotein, is probably formed by a pH dependent fusion in the endoplasmic reticulum. Such a doublet is also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. On the other hand, the envelope glycoprotein precursor of HIV-1 does not form a dimer during its processing. Experiments carried out with various inhibitors of oligosaccharide trimming enzymes suggest that transient dimerization of the glycoprotein precursor is required for its efficient transport to the Golgi apparatus and for its processing. The gp300 is useful for detecting antibodies to HIV-2 antigens in human body fluids and for raising antibodies to gp300.

REFERENCES:
patent: 4839288 (1989-06-01), Montagnier et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Dimer of the precursor of HIV-2 envelope glycoprotein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dimer of the precursor of HIV-2 envelope glycoprotein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dimer of the precursor of HIV-2 envelope glycoprotein will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-877713

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.