Diltiazem pharmaceutical spheroid formulation

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424493, 424479, 424480, 424472, 514869, A61K 916

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active

055080448

ABSTRACT:
A solid oral dosage form comprising diltiazem (or a pharmaceutically acceptable salt thereof) in controlled release form and hydrochlorothiazide in immediate release form. Preferably, the controlled release component comprises a plurality of spheroids comprising diltiazem and a spheronizing agent.

REFERENCES:
patent: 4728512 (1988-03-01), Mehta et al.
patent: 4891230 (1990-01-01), Geoghegan et al.
patent: 5156850 (1992-10-01), Wong et al.
patent: 5286497 (1994-02-01), Hendrickson et al.
Buris et al. JAMA 3/90 vol. 263 #11, pp. 1507-1512 An Assessment of Dictiazem and Hydrochlorothiazide in Hypertension.
Weinstock Chem Abstracts 117(18) 178319h Antihypertension Compositions Containing Diuretics and Angioprosin II Receptor Antagonists.
"Diuretics Versus Calcium-Channel Blockers in Systemic Hypertension: A Preliminary Multicenter Experience with Hydrochlorothiazide and Sustained-Release Diltiazem", Frishman, et al., American Journal of Cardiology, Dec. 6, 1985, vol. 56, pp. 92H-96H.
"An Assessment of Diltiazem and Hydrochlorothiazide in Hypertension" Buris, et al., JAMA, Mar. 16, 1990, vol. 263 No. 11; pp. 1507-1512.
"A dose escalation trial comparing the combination of diltiazem SR and hydrochlorothiazide with the monotherapies in patients with essential hypertension", Weir, et al. Journal of Human Hypertension (1992) vol. 6 pp. 133-138.
"Comparison of Hydrochlorothiazide and Sustained-Release Diltiaze for Mild-to-Moderate Systemic Hypertension", Frishman, et al, American Journal of Cardiol Mar. 1, 1987, vol. 59, pp. 615-623.

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