Diltiazem formulation

Details Diltiazem formulation Diltiazem formulation

1987-11-16

1990-01-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424459, 424462, 424470, 424493, 424494, 424495, 424497, A61K 962, A61K 916, A61K 926

Patent

active

048912301

ABSTRACT:
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of diltiazem from the pellet at a rate allowing controlled absorption thereof over a twelve hour period following oral administration. The pellet has a dissolution rate in vitro which when measured in a dissolution apparatus (Paddle) according to U.S. Pharmacopoeia XXI in 0.05 M KCl at pH 7.0 results in not more than 35% of the total diltiazem being released after 2 hours of measurement. Not more than 80% of the total diltiazem is released after six hours of measurement and not less than 85% of the total diltiazem is released after 13 hours of measurement.

REFERENCES:
patent: 3965255 (1976-06-01), Bloch et al.
patent: 4230687 (1980-10-01), Sair et al.
patent: 4263273 (1981-04-01), Appelgren et al.
patent: 4361546 (1982-11-01), Stricker et al.
patent: 4432966 (1984-02-01), Zeitoun et al.
patent: 4496558 (1985-01-01), DeMarinis et al.
patent: 4499066 (1985-02-01), Moro et al.
patent: 4555399 (1985-11-01), Hsiao
patent: 4592753 (1986-06-01), Panoz
patent: 4600645 (1986-07-01), Ghebre-Sellassie et al.
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4609542 (1986-09-01), Panoz et al.
patent: 4610870 (1986-09-01), Jain et al.
patent: 4666702 (1987-05-01), Junginger
patent: 4684516 (1987-08-01), Bhutani
patent: 4756911 (1988-07-01), Drost et al.
Chemical Abstracts, vol. 100, No. 18, Apr. 30, 1984, p. 367, abstract 145016c.

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