Diltiazem controlled release formulation

Details Diltiazem controlled release formulation Diltiazem controlled release formulation

1996-07-09

1998-11-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424458, 424459, 424462, 424468, 514963, A61K 958, A61K 922, A61K 914

Patent

active

058340238

ABSTRACT:
A once-a-day controlled release diltiazem formulation is described which includes:
(a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and
(b) from 50% to 80% by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder and a second layer which comprises a polymeric membrane which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem; and
(c) a unit dose containment system.

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