Diketohydrazine derivative compounds and drugs containing...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07655804

ABSTRACT:
The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification).The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).

REFERENCES:
patent: 6117870 (2000-09-01), Hosoda et al.
patent: 1274283 (2000-11-01), None
patent: 95/07269 (1995-03-01), None
patent: WO 99/17775 (1999-04-01), None
patent: WO 03/013518 (2003-02-01), None
Golub et al., Science, 286, 531-537, 1999.

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