Diketo acids with nucleobase scaffolds: anti-HIV replication...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S263200, C544S264000

Reexamination Certificate

active

07569573

ABSTRACT:
A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.

REFERENCES:
patent: 6492423 (2002-12-01), Sergio et al.
patent: 6620841 (2003-09-01), Fujishita et al.
patent: 6645956 (2003-11-01), Fujishita et al.
patent: 6803374 (2004-10-01), Priestley et al.
patent: 6803378 (2004-10-01), Walker et al.
patent: 7098201 (2006-08-01), Fujishita et al.
patent: 2003/0207922 (2003-11-01), Neuner et al.
patent: 2005/0026902 (2005-02-01), Maziasz
patent: WO 00/06529 (2000-02-01), None
Vasu Nair Rev, Med. Viro. 12;179-193, 2002.
Fauci, Science 239, 617-622 (1988).
Katz & Skalka, Annu. Rev. Biochem. 63, 133-173 (1994).
Frankel, Annu. Rev. Biochem. 67, 1-25 (1998).
De Clercq, J. Med. Chem 38, 2491-2517 (1995).
De Clercq, Clin. Microbiol Rev. 10, 674-693 (1997).
De Clercq, Nature Reviews: Drug Discovery 11, 13-25 (2002).
Johnson & Gerber, in “Advances in Internal Medicine” vol. 44, Mosby: St. Louis, 1-40 (2000).
Miller & Hazuda, Current Opinion in Microbiology, 4, 535-539 (2001).
Asante-Appiah & Skalka, Adv. Virus Res., 52, 351-369 (1999).
Nair, in “Recent Advances in Nucleosides: Chemistry and Chemotherapy,” Elsevier Science: Netherlands, 149-166 (2002).
DeClercq, Intl. J. Biochem, Cell Biol. 36, 1800-1822 (2004).
Nair, Rev. Med. Virol., 12, 179-193 (2002).
Nair, Current Pharmaceutical Design, 9, 2553-2565 (2003).
Esposito & Craigie, Adv. Virus Res. 52,319-333 (1999).
Chi and Nair, Bioorg. Med. Chem. Letter 14, 4815-4817 (2004).
Taktakishvilli et al., J. Am. Chem. Soc., 122, 5671-5677 (2000).
Wai et al., “4- Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells,” J. Med. Chem. 43, 4923-4926 (2000).
Pais, G. C. G., et al., “Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors” J. Med. Chem. 45, 3184-3194 (2002).
Marchand, C. jet al., “Structural determinants for HIV-1 integrase inhibition by beta-diketo acids” J. Biol. Chem. 277, 12596-12603 (2002).
Sechi, M. etal., “Design and Synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.” J. Med. Chem. 47, 5298-5310 (2004).
Zhang, et al., “Azido-containing aryl beta-keto acid HIV-1 integrase inhibitors” Bioorg. Med. Chem. Lett. 13, 1214-1219 (2003).
Grobler, J. A. et al., Proc. Natl. Acad. Sci. U.S.A. 99, 6661-6666 (2002).
Hazuda, D. J. et al., Science 287, 646-650 (2000).
Pannecouque, C. et al., Current Biology 12, 1169-1177 (2002).
Nair et al., “HIV Integrase Inhibitors with Nucleobase Scaffolds: Discovery of a Highly Potent Anti-HIV Agent”, J. Med. Chem; 2006; 49:445-447.

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