Diindolylmethane for the treatment of HPV infection

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S415000, C514S410000, C514S412000

Reexamination Certificate

active

07348352

ABSTRACT:
New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized to treat subjects suffering from common cutaneous warts (verrucae) and Human Papilloma Virus (HPV) related conditions of the oropharynx, larynx, genitalia, and uterine cervix.

REFERENCES:
patent: 5830887 (1998-11-01), Kelly
patent: 5895787 (1999-04-01), Arffmann et al.
patent: 5948808 (1999-09-01), Safe
patent: 6086915 (2000-07-01), Zeligs et al.
patent: 6399645 (2002-06-01), Bell et al.
patent: 6534085 (2003-03-01), Zeligs
patent: 6613792 (2003-09-01), Ellenberger et al.
patent: 6689387 (2004-02-01), Zeligs
patent: 2002/0147155 (2002-10-01), Foster et al.
patent: 2004/0072891 (2004-04-01), Zeligs
Hardman et al. “Goodman & Gilman's The Pharmacological Basis of Therapeutics” (9th ed, 1996) p. 51 and 57-58.
Schwartz et.al.Journal of Cellular Biochemistry, (1995) 58/SUPPL. 22, (210-217).
Bradlow et al. ‘Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent,’ Annals of New York Academy of Sciences, 1999, vol. 889, pp. 204-213.
Baugh SM et al., “Treatment of cervical dysplasia with indole-3-carbinol” in The Ray A. Barlow Scientific Symposium, Jan. 23, 1998, Shreveport : The Center for Excellence in Cancer Research, Treatment and Education, Louisiana State University Medical Center, Shreveport (LA), p. 3.
Bell, MC et al., “Placebo-controlled Trial of Indole-3-Carbinol in the Treatment of Cervical Dysplasia”, Mar. 1999, Gynecol. Oncol. 72:446.
Yuan F et al., “Prevention of Papillomavirus initiated cancer by the phytochemical Indole-3-Carbinol”, Proceedings of the 17thInternational Papillomavirus Conference, Jan. 9-15, 1999, p. 73.
BioResponse-DIM Indolplex Product Information Brochure, Dec. 15, 1998.
Dec. 1998 Bioresponse Letter, Dec. 29, 1998.
Zeligs MA, “Diet and Estrogen Status: The Cruciferous Connection”, 1998, J Med Food, 1:67-82.
Ponten J and Guo Z, “Precancer of the Human Cervix”, 1998, Cancer Surveys 32:201-229.
Cancer Medicine 3rd edition, 1993, JF Holland ed., Lea & Febiger, Malvern, PA p. 1633.
Molecular Biology of the Cell 2nded., 1989, Alberts, B et al., Garland Publishing, Inc., New York, pp. 1193-1194, 1204-1206.
Arbeit, JM et al., “Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice”, Apr. 1996, Proc Natl Acad Sci, USA 93:2930-2935.
Bell, MC et al., “Placebo-Controlled Trial of Indole-3-Carbinol in the Treatment of CIN”, 2000, Gynecologic Oncology, 78:123-129.
Bradfield et al., “High-performance liquid chromatographic analysis of anticarcinogenic indoles inBrassica oleracea”, 1987, J Agric Food Chem 35:46-49.
Michnovicz et al., “Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans”, 1997, J Natl Cancer Inst 89:718-23.
Ho et al., “Urinary 2/16alpha-hydroestrone ratio: correlation with serum insulin-like growth factor binding protein-3 and a potential biomarker of breast cancer risk”, 1998, Ann Acad Med Singapore 27:294-9.
Schneider et al., “Abnormal oxidative metabolism of estradiol in women with breast cancer”, 1982, Proc Natl Acad Sci USA 79:3047-52.
Bradlow et al., “2-hydroxyestrone: the ‘good’ estrogen”, 1996, J Endocrin 150:S259-S265.
Komura et al., “Catecholestrogen as a natural antioxidant”, 1996, Ann NY Acad Sci 786:419-29.
Rosen et al., “Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis”, 1998, Otolaryngol Head Neck Surg 118:810-5.
Jin et al., “Indole-3-carbinol prevents cervical cancer in human papillomavirus type 16 (HPV16) transgenic mice”, 1999, Cancer Res 59 3991-7.
Chen et al., “Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindoylmethane”, 1998, Carcinogenesis 19:1631-1639.
Ritter et al., 2001, “Oxidations of 17beta-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or beta-naphthoflavine,” Can. J. Physiol. Pharmacol. 79(6):519-32.
Dashwood, R.H., 1998, “Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?” Chem Biol. Interact., 110(1-2):1-5.
Exon, et al., 2000, “Dietary indole-3-carbinol alters immune functions in rats,” J. Toxicol. Environ. Health A., 59(4):271-9.
Gooptu et al., 2000, “Treatment of viral warts with cimetidine: and open-label study,” Clin. Exp. Dermatol. 25(3):183-5.
Michnovicz et al., 1991, “Cimetidine inhibits catechol estrogen metabolism in women,” Metabolism, 40(2):170-74.
Tse et al., 1987, “Disposition of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol (59-801), a hypoglycaemic agent in rats, dogs and monkeys,” Xenobiotica, 17(6):741-9.
Stresser et al., 1995, “The anticarcinogen 3,3'-Diindolyl-methane is an inhibitor of cytochrome P-450,” J. Biochem. Toxicol., 10(4):191-201.
Sepkovic et al., 2002, “Quantitative Determination of 3,3'-Diindolymethane in the urine of individuals receiving indole-3-carbinol,” Nutr Cancer. 2001;41(1-2):57-63.
Auborn et al., 2000 “Treatment of Human Papillomavirus Gynecologic Infections”, Clin Lab Med 20:407-22.
Bjeldanes et al., 1991, “Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8,-tetrachlorodibenzo-p-dioxin,” Proc. Natl. Acad. Sci. USA 88:9543-9547.
Chang et al., 1999, “Cytostatic and antiestrogenic effects of 2-(Indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol,” Biochem. Pharmacol. 58:825-834.
de Vet et al., 1994, “The role of cigarette smoking in the etiology of cervical dsplasia,” Epidemiology 5:631-633.
Gillner et al., 1985, “Interactions of indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver,” Mol Pharmacol 28:357-363.
Larson-Su et al., 2001, “Transplacental exposure to indole-3-carbinol induces sex-specific expression of CYP1A1 and CYP1B1 in the liver of Fischer 344 neonatal rats,” Toxicological Sci. 64:162-168.
Liu et al., 1994, “Indolo[3,2-b]carbozole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity,” J. Natl. Cancer Inst. 86:1758-1765.
Loub et al., 1975, “Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants,” J. Natl. Cancer Inst. 54:985-988.
Michnovicz et al., 1988, “Increased urinary catechol estrogen excretion in female smokers,” Steroids 52:69-83.
Michnovicz et al., 1986, “Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking,” N Engl J Med 315:1305-1309.
Riby et al., 2000, “Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells,” Biochem. Pharmacol. 60:167-177.
Shilling et al., 2001, “3,3'-diindolylmethane, a major condensation product of indole-3-carbinol, is a potent estrogen in the rainbow trout,” Toxicology and Applied Pharmacology 170:191-200.
Stresser et al., 1995, “Mechanisms of tumor modulation by indole-3-carbinol: disposition and excretion in male fisher 344 rats,” Drug Metabolism and Disposition 23:965-975.
Walboomers et al., 1999, “Human papillomavirus is a necessary cause of invasive cervical cancer worldwide,” J. Pathol. 189:12-19.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diindolylmethane for the treatment of HPV infection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diindolylmethane for the treatment of HPV infection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diindolylmethane for the treatment of HPV infection will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3973433

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.