Dihydroxyacryl

Details Dihydroxyacryl Dihydroxyacryl

1984-10-29

1986-04-22

Michl, Paul R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C14923

Patent

active

045844020

ABSTRACT:
A compound of the formula: ##STR1## where p is a whole integer from 1 to 12, and where R.sub.1 is CH.sub.2 OH or CH.sub.2 SH or CHO, m is a whole integer from 1 to 3 and R.sub.2 is H or CH.sub.2 OH. When incorporated into acrylyl-type terpolymers, the above compounds become pendant vicinal dihydroxyalkyl substituents oxidizable by metaperiodate to a pendant aldehyde form. Molecules, including proteins, bearing at least one primary amino group are coupled to the pendant aldehyde groups through Shiff base linkages followed by alkali metal cyanoborohydride reduction of the Schiff base linkages to secondary amine linkages. The study of cell adhesion to and interactions with specific molecule-bearing synthetic cell culture surfaces as well as production of specific molecule-bearing chromatographic media and enzymic reactors are enhanced or made available through the use of the invention's vicinal dihydroxyalkyl bearing acrylyl-type terpolymers.

REFERENCES:
patent: 3883299 (1975-05-01), Baumgarte et al.
patent: 4154747 (1979-05-01), Epple et al.
patent: 4180308 (1979-12-01), Mancini et al.
patent: 4390683 (1983-06-01), Yatsu et al.
patent: 4401372 (1983-08-01), Mancini et al.
Raja et al., J. Cell. Biol., vol. 97, p. 314a, Nov. 1983.
Weigel et al., Meth. in Enzymol., vol. 83, pp. 294-299, 1982.
Shainoff, Biochem. Biophys. Res. Comm., vol. 95, No. 2, pp. 690-695, 1980.
Fiddler et al., Anal. Biochem., vol. 86, pp. 716-724, 1978.
Mosbach et al., Meth. in Enzymol., pp. 53-65, 1976.
Ternynck et al., FEBS Lett., vol. 23, No. 1, pp. 24-28, 1972.
Weston et al., Biochem Biophys. Res. Comm., vol. 45, No. 6, pp. 1574-1580, 1971.

Affiliated with

Also associated with

Rating

Dihydroxyacryl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dihydroxyacryl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dihydroxyacryl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1916470