Dihydrotriazinylthiooxacephalosporins

Details Dihydrotriazinylthiooxacephalosporins Dihydrotriazinylthiooxacephalosporins

1978-07-13

1980-11-04

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544182, 42424851, 542424, C07D49800

Patent

active

042321514

ABSTRACT:
Dihydrotriazinylthiomethyl-oxacephem compounds represented by the formula: ##STR1## wherein A is amino or substituted amino; COB is carboxy, protected-carboxy or a carboxy salt; E is hydrogen or methoxy; M is hydrogen or hydroxy-protecting group; and R is lower alkyl are useful as antibacterial agents.

REFERENCES:
patent: 4091211 (1978-05-01), Montavon et al.
patent: 4138486 (1979-02-01), Narisada et al.
Kim et al., Tetrahedron Letters, No. 5, pp. 409-412 (1978).
Lednicer et al., The Organic Chemistry of Drug Synthesis, Frontispage, pp. 416-422, John Wiley and Sons, NY (1977).
Cama et al., J. Am. Chem. Soc., vol. 96, pp. 7582-7584 (1974).
Firestone et al., J. of Med. Chem., vol. 20, pp. 551 to 556 (1977).

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