Dihydrospirorenone as an antiandrogen

Details Dihydrospirorenone as an antiandrogen Dihydrospirorenone as an antiandrogen

1993-12-07

1996-10-29

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514172, A61K 31585

Patent

active

055696520

ABSTRACT:
Dihydrospirorenone, ##STR1## preferably together with an estrogen, can be used for the production of a pharmaceutical agent suitable for treatment of hormonal irregularities during premenopause (menstruation stabilization), for hormonal substitution therapy during menopause, for treatment of androgen-induced disorders and/or for contraception.

REFERENCES:
patent: 4347245 (1982-08-01), Shapiro
patent: 4502989 (1985-03-01), Kamata et al.
patent: 4584288 (1986-04-01), Nickish et al.
patent: 4729999 (1988-03-01), Young
patent: 4855289 (1989-08-01), Wester et al.
patent: 4868166 (1989-09-01), Bittler et al.
Breiner et al., "Inhibition of Androgen Receptor Binding by Natural and Synthetic Steroids in Cultured Human Genital Skin Fibroblasts," Klin. Wochenschr., 64:732-737 (1986).
Nishino et al., Arch Pharmacol., vol. 316, R49 (1981).
Nishino et al., Acta Endocrinologica, Suppl. 246, vol. 99, p. 93, Abstract 105 (1982).

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