Dihydropyrimidone derivatives as NPY antagonists

Details Dihydropyrimidone derivatives as NPY antagonists Dihydropyrimidone derivatives as NPY antagonists

1998-01-20

1999-03-30

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544316, A61K 31505, C07D40112

Patent

active

058890165

ABSTRACT:
The present invention provides a series of non-peptidergic antagonists of NPY comprising piperidine derivatives of 4-phenyl-1,4-dihydropyrimidinones of the Formula I ##STR1## wherein R, R.sup.1 and R.sup.2 are defined herein. As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

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