Dihydropyridyl cyclic imidate esters and their pharmaceutical us

Details Dihydropyridyl cyclic imidate esters and their pharmaceutical us Dihydropyridyl cyclic imidate esters and their pharmaceutical us

1982-03-22

1983-11-08

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424851, 42424854, 42424855, 424263, 544 96, 546256, 546273, 546275, A61K 3144, C07D21190, C07D26314

Patent

active

044142137

ABSTRACT:
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula ##STR1## wherein R and R.sup.1 are independently selected from hydrogen, lower alkyl or alkoxyalkyl groups; R.sup.2 is lower alkyl, aryl, or hetaryl; R.sup.3 is cycloalkyl, aryl or hetaryl, generally with electron-withdrawing substituents; R.sup.4 is lower alkyl, alkoxyalkyl, aminoalkyl, haloalkyl, or dialkylaminoalkyl; R.sup.5 is lower alkyl or aryl; m is 0 or 1; and n is 0, 1, or 2. Compounds of this series demonstrate blockage of calcium ion flux in tissue preparations in vitro and vasodilation in animal testing in vivo.

REFERENCES:
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3488359 (1970-01-01), Bossert et al.
patent: 3511847 (1970-05-01), Loev et al.
patent: 3985758 (1976-10-01), Murakami et al.
patent: 4096270 (1978-06-01), Teulon et al.
patent: 4220649 (1980-09-01), Kojima et al.
Meyers et al., Heterocycles, vol. 11, pp. 133-138 (1978).
Prous et al., Drugs of the Future, vol. VI, No. 7, (1981) pp. 427-440.

Affiliated with

Also associated with

Rating

Dihydropyridyl cyclic imidate esters and their pharmaceutical us does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dihydropyridyl cyclic imidate esters and their pharmaceutical us, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dihydropyridyl cyclic imidate esters and their pharmaceutical us will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2007489