Dihydropyridine vasodilators agents

Details Dihydropyridine vasodilators agents Dihydropyridine vasodilators agents

1991-12-10

1993-11-02

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546263, 546288, 546322, 544238, C07D21364, C07D21355, C07D21357, A61K 31435

Patent

active

052585190

ABSTRACT:
Compounds of the following formula (I): ##STR1## where R.sup.1 and R.sup.2 are alkyl or cycloalkyl, which may be substituted, R.sup.4 is aryl such as phenyl which may be substituted, L is a direct bond or an oxygen containing linking group, R is a hydrogen, alkyloxy, alkyl, halogen or haloalkyl and Het is a pyridinyl or pyridazinyl group. The compounds can be used antihypertensives or myocardial relaxants. Also part of the invention are pharmaceutical compositions, intermediates and methods of synthesis.

REFERENCES:
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patent: 4686229 (1987-08-01), Rosentreter et al.
patent: 4707470 (1987-11-01), Meyer et al.
patent: 4876254 (1989-10-01), Franckowiak et al.
patent: 4876255 (1989-10-01), Franckowiak et al.
patent: 4898865 (1990-02-01), Franckowiak et al.

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