Dihydropyridine NPY antagonists: nitrogen heterocyclic derivativ

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514290, 514307, 546 17, 546101, 546110, 546141, 546146, 546321, 546322, A61K 3116, A61K 3117, C07D40110

Patent

active

055546218

ABSTRACT:
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

REFERENCES:
patent: 4707486 (1987-11-01), Flockerzi et al.
patent: 4829076 (1989-05-01), Szil agyi et al.

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