Dihydropyridine derivatives, their preparation and their use

Details Dihydropyridine derivatives, their preparation and their use Dihydropyridine derivatives, their preparation and their use

1987-10-05

1988-09-20

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514318, 514340, 546194, 546281, 546275, A61K 31445, A61K 31455, C07D40112

Patent

active

047725966

ABSTRACT:
2-(Amino or methyl)-6-(methyl or amino)-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters have a specific class of heterocyclic groups as thealcohol moiety. These compounds have a variety of valuable activities, including antihypertensive and Ca.sup.++ -blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted benzylideneacetoacetic acid esters with appropriate amidinoacetic acid esters.

REFERENCES:
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patent: 4220649 (1980-09-01), Kojima et al.
patent: 4448964 (1984-05-01), Muto et al.
patent: 4565824 (1986-01-01), Wehinger et al.
patent: 4579859 (1986-04-01), Ueda et al.
patent: 4603135 (1986-07-01), Meguro et al.
Arzneim-Forsh., 31, 1173(1981).

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