Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-08-20
1989-12-12
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514252, 514255, 514332, 514334, 546321, 546257, 546261, 546262, 546265, 544364, 544365, C07D21186, A61K 31455
Patent
active
048868191
ABSTRACT:
Dihydropyridine derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, A, B are defined as in the specification and nontoxic acid-addition salts thereof, have an excellent calcium blocking action (Ca-antagonist), and antihypertensive action, a platelet aggregation-inhibiting action, a phosphodiesterase-inhibiting action and the like, and thus are useful as a medicine, such as a coronary vasocilator, a cerebral hyperkinemic, antihypertensive, thrombosis-preventing or -treating agents, phosphodiesterase-inhibitor or the like. Pharmaceutical compositions and methods of use are also disclosed.
REFERENCES:
patent: 4510310 (1985-04-01), Wehinger
patent: 4595690 (1986-06-01), Clark et al.
patent: 4603135 (1986-07-01), Meguro et al.
patent: 4618607 (1986-10-01), Araki
patent: 4656181 (1987-04-01), Sunkel et al.
patent: 4686222 (1987-08-01), Atkinson
Chem. Abstr., vol. 105, No. 13, 114923v (Clark).
Chem. Abstr., vol. 36, No. 5, 29638a (Bossert).
Chem. Abstr., vol. 106, No. 5, 32844G (Clark); 32841y (Poindexter).
Ashimori Atsuyuki
Fukaya Chikara
Inoue Yoshihisa
Ono Taizo
Yokoyama Kazumasa
Fan Jane T.
The Green Cross Corporation
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