Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-10-29
1990-03-20
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514233, 514333, 514334, 514356, 514307, 514311, 514338, 514339, 544 35, 544102, 546257, 546256, 546321, 546166, 546148, 546273, 546272, 546258, C07D41344, C07D40114, C07D27936, A61K 3154
Patent
active
049101951
ABSTRACT:
Dihydropyridine derivatives represented by formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.6, which may be the same or different, each represents an alkyl group, a cycloalkyl group or an alkoxyalkyl group; R.sub.4 and R.sub.5, which may be the same or different, each represents a hydrogen atom, a halogen atom, a nitro group, a halogenated alkyl group, an alkylsulfonyl group, a halogenated alkoxy group, an alkylsulfinyl group, an alkyl group, a cycloalkyl group, an alkxoy group, a cyano group, an alkoxycarbonyl group or an alkylthio group (provided that R.sub.4 and R.sub.5 are not hydrogen atoms at the same time); X represents a vinylene group or an azomethine group; A and B are each an alkylene group or an alkenylene group; R.sub.7 and R.sub.8, which may be the same or different, each represents a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, an aryl group, or a heterocyclic group (provided that R.sub.7 and R.sub.8 may combine with the adjacent nitrogen atom to form a heterocyclic ring), and acid addition salts of the dihydropyridine derivatives of formula (I).
REFERENCES:
patent: 4532248 (1985-07-01), Franckowiak et al.
patent: 4731370 (1988-03-01), Watanabe et al.
patent: 4814455 (1989-03-01), Poindexter
Medicinal Chemistry, 2nd Edition, 1960, pp. 565-571, 579-581, 600-601.
Ashimori Atsuyuki
Fukaya Chikara
Inoue Yoshihisa
Ono Taizo
Yokoyama Kazumasa
Fan Jane T.
Green Cross Corporation
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