Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-06-05
1989-07-11
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514341, 514334, 514343, 514340, 546293, 546278, 546281, 546275, 544131, 540598, 540481, 564 88, A61K 31455, C07D21196
Patent
active
048472735
ABSTRACT:
Dihydropyridine derivatives of the formula ##STR1## wherein the symbols R and R.sup.1 to R.sup.6 have the significance given in claim 1, have a pronounced calcium-antagonist activity and can accordingly be used as medicaments, especially in the control or prevention of angina pectoris, ischemia, high blood pressure and/or migraine. The compounds of formula I can be prepared by reacting an ylidene compound of the formula ##STR2## with an enamine of the formula ##STR3##
REFERENCES:
patent: 4532248 (1985-07-01), Franekowiak et al.
Burger, Medicinal Chemistry, Second Edition (1960), pp. 566, 568, 580, 600, 601.
Jaunin Roland
Ramuz Henri
Fan Jane T.
Hoffmann-La Roche Inc.
Isgro William G.
Leon Bernard S.
Saxe Jon S.
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