Dihydropyridine compounds having 1,4,4-trisubstitution useful as

Details Dihydropyridine compounds having 1,4,4-trisubstitution useful as Dihydropyridine compounds having 1,4,4-trisubstitution useful as

1986-06-09

1988-05-03

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514278, 514277, 514332, 514357, 546328, 546323, 546314, 546329, 546341, 546342, 546262, 546280, 546275, 546276, 546281, 546 16, 544238, 544333, 544360, C07D21182, A61K 3144

Patent

active

047420685

ABSTRACT:
Dihydropyridine compounds having 1,4,4-trisubstitution of the following formula (I): ##STR1## wherein R is one of --COR.sup.3, R.sup.3 being a group such as phenyl or benzyl; R.sup.4 where R.sup.4 is a heterocycle; --(CH.sub.2).sub.n NR.sup.5 R.sup.6, with R.sup.5 and R.sup.6 being alkyl or joined to define a ring; or --(CH.sub.2).sub.n COOR.sup.7, with R.sup.7 being alkyl or benzyl.

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Comptes. Rendus. Acad. Bu. Sci., "Preparation of .beta.,.beta.Diphenylglutaric Acid and its Derivatives", H. Ivanov et al., 18(6) 1965.
Indian Journal of Chemistry, "Decarboxylative Cleavage During Friedel-Crafts Reaction . . . ", U. V. Korgaonkar et al., vol. 20B, pp. 572-574, Jul. 1981.
Tetrahedron Letters, No. 4, "2-Amino-1,2,3,4-Tetrahydropyridines", G. Fraenkel et al., pp. 327-330, 1978.
Synthesis, "Dihydropyridines; V*. Synthesis of 4,4-Disubstituted 1,4-Dihydropyridines . . . ", Lutz-F. Tietze et al., pp. 190-192, Mar. 1986.
J. Am. Chem. Soc., "Generation of a Stable Spiro Dihydroaromatic Anion", vol. 94, No. 13, pp. 4732-4734, Jun. 28, 1972, Fraenkel et al.
J. Am. Chem. Soc, "Generation of Spirodihydroaromatic Anions, Chemistry and .sup.13 C NMR", S.O.A. Rizvi et al., vol. 101, No. 16, pp. 4488-4492, Aug. 1, 1979.
J. of Chem., "The Synthesis and Properties of Some Simple 1,4-Dihydropyridines", E. M. Kosower et al., vol. 27, pp. 3764-3771 (1962).
Spectroskopische und elektrochemische Eigenschaften N-Substituierter 1,4-Dihydro-4,4-dimethylpyridine, Liebigs Ann. Chem. Hesse et al., (1982), pp. 2079-2086.

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