Dihydropyridine anti-ischaemic and antihypertensive agents

Details Dihydropyridine anti-ischaemic and antihypertensive agents Dihydropyridine anti-ischaemic and antihypertensive agents

1983-07-19

1985-05-07

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546278, 546270, 546167, 546274, 546256, 546271, 546283, 544333, A61K 3144, C07D40112

Patent

active

045157995

ABSTRACT:
1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl; R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; Y is --(CH.sub.2).sub.n --, --CH.sub.2 CH(CH.sub.3)-- or --CH.sub.2 C(CH.sub.3).sub.2 13 ; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may optionally be substituted by one or more C.sub.1 -C.sub.4 alkyl, phenyl, benzyl, CN, --N(R.sup.3).sub.2, (CH.sub.2).sub.m CO.sub.2 H, (CH.sub.2).sub.m CO.sub.2 (C.sub.1 -C.sub.4 alkyl) or (CH.sub.2).sub.m CON(R.sup.3).sub.2 group wherein each R.sup.3 is independently H or C.sub.1 -C.sub.4 alkyl and m is 0 or 1; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.

REFERENCES:
patent: 3905983 (1975-09-01), Bossert et al.
patent: 3943140 (1976-03-01), Bossert et al.
patent: 3946027 (1976-03-01), Bossert et al.
patent: 3946028 (1976-03-01), Bossert et al.
patent: 4177278 (1979-12-01), Bossert et al.
patent: 4188395 (1980-02-01), Bossert et al.
patent: 4430333 (1984-02-01), Campbell et al.

Affiliated with

Also associated with

Rating

Dihydropyridine anti-ischaemic and antihypertensive agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dihydropyridine anti-ischaemic and antihypertensive agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dihydropyridine anti-ischaemic and antihypertensive agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1799519