Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-02-21
1986-10-07
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546276, 546269, 546257, 546284, 546281, 546280, 546277, 514314, 514337, 514338, 514339, 514342, 514343, C07D40112, A61K 3141
Patent
active
046160248
ABSTRACT:
1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl: R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; Y is --(CH.sub.2).sub.n --, --CH.sub.2 CH(CH.sub.3)-- or --CH.sub.2 C(CH.sub.3).sub.2 --; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may optionally be substituted by one or more C.sub.1 -C.sub.4 alkyl, phenyl, benzyl, CN, --N(R.sup.3).sub.2, (CH.sub.2).sub.m CO.sub.2 H, (CH.sub.2).sub.m CO.sub.2 (C.sub.1 -C.sub.4 alkyl) or (CH.sub.2).sub.m CON(R.sup.3).sub.2 group wherein each R.sup.3 is independently H or C.sub.1 -C.sub.4 alkyl and m is 0 or 1; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.
REFERENCES:
patent: 3905983 (1975-09-01), Bossert et al.
patent: 3943140 (1976-03-01), Bossert et al.
patent: 3946027 (1976-03-01), Bossert et al.
patent: 3946028 (1976-03-01), Bossert et al.
patent: 4177278 (1979-12-01), Bossert et al.
patent: 4188395 (1980-02-01), Bossert et al.
patent: 4404378 (1983-09-01), Miyano et al.
patent: 4430332 (1984-02-01), Campbell et al.
patent: 4430333 (1984-02-01), Campbell et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
Bossert et al., Angew. Chem. Int. Ed. Engl. 20, 762-769, 1981.
Campbell Simon F.
Cross Peter E.
Stubbs John K.
Fan Jane T.
Frost Albert E.
Knuth Charles J.
McManus James M.
Pfizer Inc.
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