Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-01-16
1985-10-22
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
546277, 546278, 514231, 546280, 546281, 514232, 546283, 546284, 514236, 514245, 514252, 514269, 514314, 514318, 514333, 514336, 514338, 514339, 514340, 514341, 514342, 514343, 544122, 544131, 544212, 544333, 544364, 546167, 546177, 546193, 546194, 546256, 546269, 546270, 546271, 546272, 546274, 546276, A61K 3144, A61K 31535, C07D41314, C07D41712
Patent
active
045489351
ABSTRACT:
Dihydropyridine anti-ischaemic and anti-hypertensive agents of the formula: ##STR1## and their pharmaceutically acceptable salts; wherein R is aryl or heteroaryl; R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 or 2-methoxyethyl; n is 1 or 2; m is 1, 2 or 3; X is a 5 or 6 membered aromatic heterocyclic group which is linked to the adjacent alkoxymethyl group by a ring carbon atoms thereof; and Z is a group--NR.sup.3 R.sup.4 or a 5 to 6 membered nitrogen containing heterocyclic group; where R.sup.3 is H or C.sub.1 -C.sub.4 alkyl; R.sup.4 is H, C.sub.1 -C.sub.4 alkyl, CO(C.sub.1 -C.sub.4 alkyl), COCF.sub.3, CONR.sup.5 R.sup.6, SO.sub.2 (C.sub.1 -C.sub.4 alkyl) or a heterocyclic or SO.sub.2 -heterocyclic group, wherein the heterocyclic group is optionally substituted; R.sup.5 and R.sup.6 and each independently H or C.sub.1 -C.sub.4 alkyl or taken together with the nitrogen atom to which they are attached, they form a pyrrolidinyl, piperidyl, morpholino, piperazinyl or N-(C.sub.1 -C.sub.4 alkyl)piperazinyl group.
REFERENCES:
patent: 4430333 (1984-02-01), Campbell et al.
Alker David
Campbell Simon F.
Cross Peter E.
Frost Albert E.
Knuth Charles J.
McManus James M.
Pfizer Inc.
Ramsuer Robert W.
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