Dihydropyridine-5-phosphonic acid cyclic propylene ester

Details Dihydropyridine-5-phosphonic acid cyclic propylene ester Dihydropyridine-5-phosphonic acid cyclic propylene ester

1986-04-14

1989-12-05

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

546 21, 514 85, 544337, 558178, 560172, A61K 31675, C07F 958, C07F 965, C07F 940

Patent

active

048852848

ABSTRACT:
A compound of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 which may be the same or different, is hydrogen or C.sub.1 -C.sub.4 alkyl; one of X.sup.1 and X.sup.2 is nitro, fluroine, chlorine, difluoromethyoxy or trifluoromethyl and the other is hydrogen, or both of X.sup.1 and X.sup.2 are chlorine; and Y is ##STR2## wherein A is C.sub. -C.sub.6 alkylene, each of Ar.sup.1 and Ar.sup.2 which may be the same or different, is phenyl which may be substituted by chlorine, fluorine or C.sub.1 -C.sub.3 alkoxy, and m is an integer of from 0 to 4, or Y is ##STR3## wherein A, Ar.sup.1 and Ar.sup.2 are as defined above when that both X.sup.1 and X.sup.2 are chlorine; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4535073 (1985-08-01), Kimura et al.
patent: 4576934 (1986-03-01), Seto et al.
Fujimoto et al., European Journal of Pharmacology, pp. 243-254, (1986).
Loev et al., J. Med. Chem., vol. 17(9), 1974, pp. 956-965.
Merck Index, 10th Ed., (1983), p. 164, Entry 1160.

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