Dihydropyridine-3, 5-dicarboxylic acid ester derivatives

Details Dihydropyridine-3, 5-dicarboxylic acid ester derivatives Dihydropyridine-3, 5-dicarboxylic acid ester derivatives

1995-06-19

1997-04-01

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21190

Patent

active

056167156

ABSTRACT:
A process is provided for producing diastereoisomer A or a pharmaceutically acceptable acid addition salt of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester which comprises subjecting a mixture of diastereoisomers A and B of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester to column chromatography using silica gel as a carrier and a mixture of ethyl acetate and acetic acid as an eluant, and then separating the acetate of diastereoisomer A from the eluate, or treating the acetate with a base, or further treating the resulting diastereoisomer A with a pharmaceutically acceptable acid.

REFERENCES:
patent: 4463176 (1984-07-01), Dennis
Kawashima, Gen. Pharmacol., vol. 22(2), pp. 263-266, 1991.
Tamazawa, J. Med. Chem., vol. 29(12), pp. 2504-2511, 1986.

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