Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanola

Details Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanola Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanola

1985-09-23

1991-02-19

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 5142228, 5142238, 5142315, 546321, 546284, 544131, C07D21186, A61K 31455

Patent

active

049944762

ABSTRACT:
A series of compounds useful in treating cardiovascular disorders due to the combined expression of both .beta.-block and calcium-block activity by these agents. This useful combination of actions is effected by a novel combination of structural subunits forming these compounds. Essentially, .beta.-blocking aryloxypropanolamine moieties are attached via their aryl ring or amino nitrogen at one of the carboxylate groups of calcium-blocking 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates. These compounds are prepared from new 4-aryl-1,4-dihydropyridine intermediate compounds.

REFERENCES:
patent: 3485847 (1969-12-01), Bossert et al.
patent: 4532248 (1985-07-01), Franckowink et al.
Baldwin et al., J. Med. Chem., 24, pp. 628-631 (1981).
Bossert, F. et al., "4-Aryldihydropyridine", Angew. Chem. Int. Ed. Engl. 20, (1981), pp. 762-769.

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