Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2008-08-15
2010-10-05
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
07807831
ABSTRACT:
Disclosed are new dihydropteridinones of the formula (I)wherein the groups L, R1, R2, R3, R4and R5have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
REFERENCES:
patent: 4957922 (1990-09-01), Lammens et al.
patent: 5167949 (1992-12-01), Ferrand et al.
patent: 5424311 (1995-06-01), Billhardt-Troughton et al.
patent: 5698556 (1997-12-01), Chan
patent: 6096924 (2000-08-01), Studer et al.
patent: 6174895 (2001-01-01), Kleinman
patent: 6605255 (2003-08-01), Kroll et al.
patent: 6806272 (2004-10-01), Bauer et al.
patent: 6861422 (2005-03-01), Hoffmann et al.
patent: 7238807 (2007-07-01), Duran et al.
patent: 7241889 (2007-07-01), Hoffmann et al.
patent: 7332491 (2008-02-01), Grauert et al.
patent: 7371753 (2008-05-01), Stadtmueller et al.
patent: 7414053 (2008-08-01), Grauert et al.
patent: 7439358 (2008-10-01), Linz et al.
patent: 7547780 (2009-06-01), Grauert et al.
patent: 7625899 (2009-12-01), Hoffmann et al.
patent: 7626019 (2009-12-01), Duran et al.
patent: 7629460 (2009-12-01), Grauert et al.
patent: 2002/0183292 (2002-12-01), Pairet et al.
patent: 2002/0183293 (2002-12-01), Banerjee et al.
patent: 2003/0130286 (2003-07-01), Denny et al.
patent: 2004/0029885 (2004-02-01), Bauer et al.
patent: 2004/0147524 (2004-07-01), Bauer et al.
patent: 2004/0176380 (2004-09-01), Hoffmann et al.
patent: 2005/0014760 (2005-01-01), Hoffmann et al.
patent: 2005/0014761 (2005-01-01), Hoffmann et al.
patent: 2005/0148501 (2005-07-01), Palmer et al.
patent: 2005/0159414 (2005-07-01), Nickolaus et al.
patent: 2005/0165010 (2005-07-01), Nickolaus et al.
patent: 2006/0004014 (2006-01-01), Hoffmann et al.
patent: 2006/0009457 (2006-01-01), Hoffmann et al.
patent: 2006/0025411 (2006-02-01), Hoffmann et al.
patent: 2006/0035902 (2006-02-01), Linz et al.
patent: 2006/0035903 (2006-02-01), Mohr et al.
patent: 2006/0046989 (2006-03-01), Grauert et al.
patent: 2006/0047118 (2006-03-01), Stadtmueller et al.
patent: 2006/0052383 (2006-03-01), Grauert et al.
patent: 2006/0058311 (2006-03-01), Munzert et al.
patent: 2006/0074088 (2006-04-01), Munzert et al.
patent: 2006/0079503 (2006-04-01), Schwede et al.
patent: 2007/0208027 (2007-09-01), Duran et al.
patent: 2007/0213528 (2007-09-01), Duran et al.
patent: 2007/0213529 (2007-09-01), Duran et al.
patent: 2007/0213530 (2007-09-01), Duran et al.
patent: 2007/0213531 (2007-09-01), Duran et al.
patent: 2007/0213534 (2007-09-01), Duran et al.
patent: 2007/0219369 (2007-09-01), Duran et al.
patent: 2008/0108812 (2008-05-01), Grauert et al.
patent: 2008/0113992 (2008-05-01), Grauert et al.
patent: 2008/0171747 (2008-07-01), Hoffman et al.
patent: 2008/0177066 (2008-07-01), Linz et al.
patent: 2008/0194818 (2008-08-01), Grauert et al.
patent: 2008/0221099 (2008-09-01), Munzert et al.
patent: 2008/0293944 (2008-11-01), Hoffmann et al.
patent: 2008/0319190 (2008-12-01), Grauert et al.
patent: 2008/0319192 (2008-12-01), Grauert et al.
patent: 2008/0319193 (2008-12-01), Grauert et al.
patent: 2009/0018333 (2009-01-01), Grauert et al.
patent: 2009/0030004 (2009-01-01), Linz et al.
patent: 2009/0124628 (2009-05-01), Hoffmann et al.
patent: 2009/0143379 (2009-06-01), Mohr et al.
patent: 2009/0238828 (2009-09-01), Munzert et al.
patent: 2009/0280115 (2009-11-01), Maier et al.
patent: 2009/0298840 (2009-12-01), Linz et al.
patent: 2458699 (2003-03-01), None
patent: 2517020 (2004-10-01), None
patent: 2517010 (2004-11-01), None
patent: 2576290 (2006-02-01), None
patent: 143478 (1985-06-01), None
patent: 347146 (1989-12-01), None
patent: 0399856 (1990-11-01), None
patent: 0429149 (1991-05-01), None
patent: 2287583 (2007-12-01), None
patent: 9609045 (1996-03-01), None
patent: 9634867 (1996-11-01), None
patent: 9636597 (1996-11-01), None
patent: 9811893 (1998-03-01), None
patent: 0119825 (2001-03-01), None
patent: 0170741 (2001-09-01), None
patent: 0178732 (2001-10-01), None
patent: 02057261 (2002-07-01), None
patent: 02076954 (2002-10-01), None
patent: 02076985 (2002-10-01), None
patent: 03020722 (2003-03-01), None
patent: 03093249 (2003-11-01), None
patent: 2004014899 (2004-02-01), None
patent: 2004076454 (2004-09-01), None
patent: 2004093848 (2004-11-01), None
patent: 2005067935 (2005-07-01), None
patent: 2006/018182 (2006-02-01), None
patent: 2006/018221 (2006-02-01), None
patent: 2006018185 (2006-02-01), None
patent: 2006018220 (2006-02-01), None
patent: 2006018221 (2006-02-01), None
patent: 2006021378 (2006-03-01), None
patent: 2007090844 (2007-08-01), None
patent: 2009019205 (2009-02-01), None
Masuda, et al., Oncogene (2003) 22, 1012-1023.
Ito, et al., “Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid” Anticancer Research, 2004, vol. 24, No. 1, pp. 259-263 (hhtp://cat.inist.fr/?aModele=afficheN&cpsidt=15622521 Nov. 17, 2006—Abstract).
Mito, et al., “Expression of Polo-Like Kinase (PLK1) in non-Hodgkin's lymphomas,” Leuk. Lymphoma, Feb. 2005, 46(2): 225-31 (PubMed abstract).
Verschuren, et al., “The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin” J. Gen. Virology (2004), 85, pp. 1347-1361.
Tor Ahlenius, Listing of cardiovascular disorders/diseases, Karolinska Instiutet Library, Stockholm, Sweden, http://www.mic.ki.se/diseases/c14.html, pp. 1-34, Apr. 2007.
Wolf, Donald E., et al., “The Structure of Rhizopterin”, J. Am. Chem. Soc., vol. 69, pp. 2753-2759, 1947.
Ferrand, G. et al: “Synthesis and potential antiallergic activity of new pteridinones and related compounds.” European Journal of Medicinal Chemistry, Vo. 31, #4, 1996, pp. 273-280.
Kimball, S.D., et al; Ann. Reports Med. Chem., vol. 36,2001, pp. 139-148.
Savelli, F.& Boido, A;. “Heterocyclic System Part II-Synthesis of New Pyrido [1′2′:4,5] pyrazino [3,2-d] pyrimidines”; Bollettino Chimico Farmaceutico, 131(8), 309-12, Sep. 1992.
Katherine Arnold, “Collaboration to Play Key Role in NCI's Future, Director Says” Journal of the National Cancer Institute, Jun. 5, 2002, pp. 790-792, vol. 94, No. 11. Http://jncicancerspectrum.oxfordjournals.org/cgi/content/full/jnci;94/11/790.
The Merck Manual of Medical Information—Home Edition, Section 17, Parasitic Infections, Chapter 184 on the web site http://www.merck.com/mrkshared/mmanual—home/sec17/184.jsp, downloaded on Nov. 26, 2003.
Takai, et al., Oncongene, 2005, 24, pp. 287-291.
Karolinska Institutet, listing of cardiovascular disorders/diseases.
US Office Action mailed Dec. 10, 2003, U.S. Appl. No. 10/226,710.
US Office Action mailed Apr. 28, 2004, U.S. Appl. No. 10/374,876.
ACPS Meeting, Background Information. “Scientific considerations of plymorphism in pharmaceutical solids: abbreviated new drug applications”. Oct. 2002.
Ahmad, N. “Polo-like kinase (Plk) 1: a novel target for the treatment of prostate cancer”. The FASEB Journal. 2004, 18:5-7. Dept of Dermatology, Univ. Wisconsin, pp. 5-7.
BBC News/Health, Killer Breast Cancern Therapy Hope, www.newsvote.bbc/co./uk, downloaded Mar. 26, 2009.
Bennett, J.C., et al., “Textbook of Medicine”, Part XIV, Oncology, 1997.
Blain, S. W. et al., “Differential interaction of the cyclin-dependent kinase (Cdk) Inhibitor p27KIP with cyclin A-Cdk2 and cyclin D2-Cdk4”. The Journal of Biological Chemistry, vol. 272, No. 41, Issue Oct. 10, 1997, pp. 25862-25872.
Dipolar aprotic solvent. Exhibit A, IUPAC Compendium of Chemical Terminology, 2nd Edition, 1997.
Doerwald, F.Z. Book Wiley-VCH Verlag GmbH & Co. KGaA, “Side reactions in organice synthesis: A Guide to Successful Synthesis Design”. 2005.
Eurasian Opinion, Appln No. 2007/00389/28, Maly Slatoustinsky per., d.10, kv.15, 101000 Moscow, Russia, “EVROMARKPAT”, 2007.
Ghandi, L., et al., “An Open-Label Phase II Trial of the PLK Inhibitor BI 2536 in Patients with Sensitive Relapse Small Cell Lung Cancer”. ASCO Meeting 2009.
Giro
Grauert Matthias
Hoffmann Matthias
Boehringer Ingelheim International GmbH
Bottino Anthony P.
Devlin Mary-Ellen M.
Jaisle Cecilia M
Morris Michael P.
LandOfFree
Dihydropteridione derivatives, process for their manufacture... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dihydropteridione derivatives, process for their manufacture..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dihydropteridione derivatives, process for their manufacture... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4189307