Dihydropteridione derivatives, process for their manufacture...

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S231000, C544S251000, C544S115000

Reexamination Certificate

active

07629460

ABSTRACT:
Disclosed are new dihydropteridinones of the formula (I)wherein the groups L, R1, R2, R3, R4and R5have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.

REFERENCES:
patent: 4957922 (1990-09-01), Lammens et al.
patent: 5167949 (1992-12-01), Ferrand et al.
patent: 5424311 (1995-06-01), Billhardt-Troughton et al.
patent: 5698556 (1997-12-01), Chan
patent: 6174895 (2001-01-01), Kleinman
patent: 6605255 (2003-08-01), Kroll et al.
patent: 6806272 (2004-10-01), Bauer et al.
patent: 6861422 (2005-03-01), Hoffmann et al.
patent: 7238807 (2007-07-01), Duran et al.
patent: 7241889 (2007-07-01), Hoffmann et al.
patent: 7332491 (2008-02-01), Grauert et al.
patent: 7371753 (2008-05-01), Stadtmueller et al.
patent: 2002/0183292 (2002-12-01), Pairet et al.
patent: 2002/0183293 (2002-12-01), Banerjee et al.
patent: 2003/0130286 (2003-07-01), Denny et al.
patent: 2004/0029885 (2004-02-01), Bauer et al.
patent: 2004/0147524 (2004-07-01), Bauer et al.
patent: 2004/0176380 (2004-09-01), Hoffmann et al.
patent: 2005/0014760 (2005-01-01), Hoffmann et al.
patent: 2005/0014761 (2005-01-01), Hoffmann et al.
patent: 2005/0148501 (2005-07-01), Palmer et al.
patent: 2005/0159414 (2005-07-01), Nickolaus et al.
patent: 2005/0165010 (2005-07-01), Nickolaus et al.
patent: 2006/0004014 (2006-01-01), Hoffmann et al.
patent: 2006/0009457 (2006-01-01), Hoffmann et al.
patent: 2006/0025411 (2006-02-01), Hoffmann et al.
patent: 2006/0035902 (2006-02-01), Linz et al.
patent: 2006/0035903 (2006-02-01), Mohr et al.
patent: 2006/0046989 (2006-03-01), Grauert et al.
patent: 2006/0047118 (2006-03-01), Stadtmueller et al.
patent: 2006/0052383 (2006-03-01), Grauert et al.
patent: 2006/0058311 (2006-03-01), Munzert et al.
patent: 2006/0074088 (2006-04-01), Munzert et al.
patent: 2006/0079503 (2006-04-01), Schwede et al.
patent: 2008/0108812 (2008-05-01), Grauert et al.
patent: 2008/0113992 (2008-05-01), Grauert et al.
patent: 2008/0171747 (2008-07-01), Hoffman et al.
patent: 2008/0177066 (2008-07-01), Linz et al.
patent: 2008/0194818 (2008-08-01), Grauert et al.
patent: 2008/0293944 (2008-11-01), Hoffmann et al.
patent: 2008/0319190 (2008-12-01), Grauert et al.
patent: 2009/0143379 (2009-06-01), Mohr et al.
patent: 2458699 (2003-03-01), None
patent: 2517020 (2004-10-01), None
patent: 2517010 (2004-11-01), None
patent: 2576290 (2006-02-01), None
patent: 143478 (1985-06-01), None
patent: 347146 (1989-12-01), None
patent: 0399856 (1990-11-01), None
patent: 0429149 (1991-05-01), None
patent: 2287583 (2007-12-01), None
patent: 01/19825 (2001-03-01), None
patent: 0170741 (2001-09-01), None
patent: 0178732 (2001-10-01), None
patent: 02057261 (2002-07-01), None
patent: 02076954 (2002-10-01), None
patent: 02076985 (2002-10-01), None
patent: 03/020722 (2003-03-01), None
patent: 03093249 (2003-11-01), None
patent: 2004014899 (2004-02-01), None
patent: 2004076454 (2004-09-01), None
patent: 2004093848 (2004-11-01), None
patent: 2005067935 (2005-07-01), None
patent: 2006/018182 (2006-02-01), None
patent: 2006/018221 (2006-02-01), None
patent: 2006/021378 (2006-03-01), None
Masuda, et al., Oncogene (2003) 22, 1012-1023.
Ito, et al., “Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid” Anticancer Research, 2004, vol. 24, No. 1, pp. 259-263 (hhtp://cat.inist.fr/?aModele=afficheN&cpsidt=15622521 Nov. 17, 2006—Abstract).
Mito, et al., “Expression of Polo-Like Kinase (PLK1) in non-Hodgkin's lymphomas,” Leuk. Lymphoma, Feb. 2005, 46(2): 225-31 (PubMed abstract).
Verschuren et al., “The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin” J. Gen. Virology (2004), 85, pp. 1347-1361.
Tor Ahlenius, Listing of cardiovascular disorders/diseases, Karolinska Instiutet Library, Stockholm, Sweden, http://www.mic.ki.se/diseases/cl4.html, pp. 1-34, Apr. 2007.
Wolf, Donald E., et al., “The Structure of Rhizopterin”, J. Am. Chem. Soc., vol. 69, pp. 2753-2759, 1947.
Ferrand, G. et al: “Synthesis and potential antiallergic activity of new pteridinones and related compounds.” European Journal of Medicinal Chemistry, Vo. 31, #4, 1996, pp. 273-280.
Kimball, S.D., et al; Ann. Reports Med. Chem., vol. 36,2001, pp. 139-148.
Savelli, F. & Boido, A;. “Heterocyclic System Part II-Synthesis of New Pyrido [1′2′:4,5] pyrazino [3,2-d] pyrimidines”; Bollettino Chimico Farmaceutico, 131(8), 309-12, Sep, 1992.
Katherine Arnold, “Collaboration to Play Key Role in NCI's Future, Director Says” Journal of the National Cancer Institute, Jun. 5, 2002, pp. 790-792, vol. 94, No. 11. Http://jncicancerspectrum.oxfordjournals.org/cgi/content/full.jnci;94/11/790.
The Merck Manual of Medical Information—Home Edition, Section 17, Parasitic Infections, Chapter 184 on the web site http://www.merck.com/mrkshared/mmanual—home/sec17/184.jsp, downloaded on Nov. 26, 2003.
Takai, et al., Oncongene, 2005, 24, pp. 287-291.
Karolinska Institutet, listing of cardiovascular disorders/diseases, 2007.
US Office Action mailed Dec. 10, 2003, U.S. Appl. No. 10/226,710.
US Office Action mailed Apr. 28, 2004, U.S. Appl. No. 10/374,876.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Dihydropteridione derivatives, process for their manufacture... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dihydropteridione derivatives, process for their manufacture..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dihydropteridione derivatives, process for their manufacture... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4137765

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.