Dihydropteridione derivatives, process for their manufacture...

Details Dihydropteridione derivatives, process for their manufacture... Dihydropteridione derivatives, process for their manufacture...

2005-08-24

2008-08-19

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S249000, C514S251000, C544S118000, C544S256000, C544S258000, C544S166000, C544S175000, C544S402000, C544S257000

Reexamination Certificate

active

07414053

ABSTRACT:
Disclosed are new dihydropteridinones of the formula (I)wherein the groups L, R1, R2, R3, R4and R5have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.

REFERENCES:
patent: 5167949 (1992-12-01), Ferrand et al.
patent: 5424311 (1995-06-01), Billhardt-Troughton et al.
patent: 5698556 (1997-12-01), Chan
patent: 6806272 (2004-10-01), Bauer et al.
patent: 6861422 (2005-03-01), Hoffmann et al.
patent: 7241889 (2007-07-01), Hoffmann et al.
patent: 2003/0130286 (2003-07-01), Denny et al.
patent: 2005/0014760 (2005-01-01), Hoffmann et al.
patent: 2005/0014761 (2005-01-01), Hoffmann et al.
patent: 2006/0004014 (2006-01-01), Hoffmann et al.
patent: 2006/0009457 (2006-01-01), Hoffmann et al.
patent: 2006/0025411 (2006-02-01), Hoffmann et al.
patent: 2006/0052383 (2006-03-01), Grauert et al.
patent: 2006/0058311 (2006-03-01), Munzert et al.
patent: 2006/0074088 (2006-04-01), Munzert et al.
patent: 2006/0079503 (2006-04-01), Schwede et al.
patent: 2458699 (2003-03-01), None
patent: 2517020 (2004-10-01), None
patent: 0399856 (1990-11-01), None
patent: 0429149 (1991-05-01), None
patent: WO01/19825 (2001-03-01), None
patent: 02057261 (2002-07-01), None
patent: 02076954 (2002-10-01), None
patent: 02076985 (2002-10-01), None
patent: WO03/020722 (2003-03-01), None
patent: 03093249 (2003-11-01), None
patent: 2004014899 (2004-02-01), None
patent: WO2004/076454 (2004-09-01), None
Background Information for the Oct. 2002 ACPS Meeting.
Souillac, et al., Characterization of Delivery Systems, Differential Scanning Calorimetry, pp. 217-221 (in Encyclopedia of Controlled Drug Delivery, 1999, John Wiley & Sons, pp. 212-227).
Disorders Index of the National Institute of Neurological Disorders and Stroke, http://www.ninds.nih.gov/disorders/disorder—index.htm?css=print.
Masuda, et al., Oncogene (2003) 22, 1012-1023.
Ito, et al., Anticancer Research, 2004, Vo. 24, No. 1, pp. 259-263 (Abstract).
Mito, et al., Leuk. Lymphoma, Feb. 2005, 46(2): 225-31 (PubMed abstract).
Verschuren, et al., J. Gen. Virology (2004), 85, 1347-1361.
Karolinska Institutet, listing of cardiovascular disorders/diseases.
Ito, et al., Anticancer Research, 2004, vol. 24, No. 1, pp. 259-263 (Abstract).
Takai, et al., Oncogene, 2005, 24, pp. 287-291.
Wolf, Donald E., et al., “The Structure of Rhizopterin”, J. Am. Chem. Soc., vol. 69, pp. 2753-2759, 1947.
Ferrand, G. et al: “Synthesis and potential antiallergic activity of new pteridinones and related compounds.” European Journal of Medicinal Chemistry, vol. 31, #4, 1996, pp. 273-280.
Kimball, S.D., et al; Ann. Reports Med. Chem., vol. 36,2001, pp. 139-148.
Savelli, F.& Boido, A;. “Heterocyclic System Part II-Synthesis of New Pyrido [1′2′:4,5] pyrazino [3,2-d] pyrimidines”; Bollettino Chimico Farmaceutico, 131(8), 309-12, Sep. 1992.
Katherine Arnold, “Collaboration to Play Key Role in NCI's Future, Director Says” Journal of the National Cancer Institute, Jun. 5, 2002, pp. 790-792, vol. 94, No. 11. Http://jncicancerspectrum.oxfordjournals.org/cgi/content/full/jnci;94/11/790.
The Merck Manual of Medical Information—Home Edition, Section 17, Parasitic Infections, Chapter 184 on the web site http://www.merck.com/mrkshared/mmanual—home/sec17/184.jsp, downloaded on Nov. 26, 2003.

Affiliated with

Also associated with

Rating

Dihydropteridione derivatives, process for their manufacture... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dihydropteridione derivatives, process for their manufacture..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dihydropteridione derivatives, process for their manufacture... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4000060