Dihydrodipicolinate reductase crystals and three dimensional str

Details Dihydrodipicolinate reductase crystals and three dimensional str Dihydrodipicolinate reductase crystals and three dimensional str

1994-04-28

1996-09-10

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C12N 902

Patent

active

055545220

ABSTRACT:
This invention relates to dihydrodipicolinate reductase crystals and to methods of growing said crystals. This invention is further directed to the utilization of said crystals to determine the three dimensional structure of dihydrodipicolinate reductase. Compounds which inhibit the activity of dihydrodipicolinate reductase in bacteria and in plants can be developed utilizing the three dimensional structure of dihydrodipicolinate reductase.

REFERENCES:
patent: 4833233 (1989-05-01), Carter
Varughese et al., Proc. Natl. Acad. Sci, USA, vol. 89, 6080-6084, 1992.
Goldberg et al., J. Mol. Biol., 225, 909-911, 1992.
Lu et al., J. Mol. Biol., 224, 277-279, 1992.
Cuemer et al., J. Gen. Micro., 134, 3221-3229, 1988.
Laber et al., BC PC Monogr., '42 (Prospects Amino Acid Biosynth. Inhib. Crop Prot. Pharm. Chem.) pp. 81-83, 1989.
Bonner et al., Methods Plant Biochem., 3, 297-313, 1990.
Cheremisinoff et al., Biotechnology: Applications & Research, pp. 545-546, 1985.

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