Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-11-10
1995-06-13
Robinson, Douglas W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536120, C07H 704, C07H 1504, A61K 3170
Patent
active
054244064
ABSTRACT:
A method for treatment of diabetes, which comprises administering to a patient with diabetes an effective amount of a dihydrochalcone derivative of the formula: ##STR1## wherein Ar is an aryl group, R.sup.1 is a hydrogen atom or an acyl group, R.sup.2 is a hydrogen atom, an acyl group or .alpha.-D-glucopyranosyl group, or R.sup.1 and R.sup.2 may combine together to form a substituted methylene group, R.sup.3 and R.sup.4 are each a hydrogen atom or an acyl group, OR.sup.5 is a protected or unprotected hydroxy group or a lower alkoxy group; or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 3984394 (1976-10-01), Westall et al.
patent: 4031260 (1977-06-01), Westall et al.
patent: 4665058 (1987-05-01), Diedrich et al.
patent: 4684627 (1987-08-01), Leveen et al.
patent: 4760135 (1988-07-01), Diedrich et al.
patent: 4840939 (1989-06-01), Leveen et al.
patent: 5110801 (1992-05-01), Leveen et al.
Effect of a Synthetic Dihydrochalcone Sweetener (Chinoin-401) on Carbohydrate Metabolism, P. Pzabo et al., Acta Alimentaria, vol. 11 (1). pp. 31-37.
Hyperglycaemia as an inducer as well as a consequence of impared islet cell function and insulin resistance: implications for the management of Diabetes, Diabetologia, 28 (1985), 119-121.
Guidelines for Toxicity Studies of Drugs, Guidelines for Non-Clinical Test of Drugs, Ministry of Health and Welfare of Japan, 114-118.
Characterization of New Oral Antidiabetic Agent CS-045, T. Fujiwara et al., Diabetes, 37, (1988).
Dorland's Medical Dictionary, 27 ed., pp. 460-461 (1988).
Antiobesity and antidiabetic actions of a new potent disaccharidase inhibtor in genetically obese-kiabetic mice, KKA(y), H. Odaka et al., J. Nutr Sci Vitaminol, 38 (1992), Abstract.
D. Diedrich (1963) Biochim. Biophys. Acta, (71) 688-700.
Rosetti et al. (1990) Diabetes Care 13(6), 610-630.
Rosetti et al. (1987) J. Clin. Invest. (79) 1510-1515.
Rosetti et al. (1987) J. Clin. Invest. (80) 1037-1044.
Kahn et al. (1991) J. Clin. Invest. (87) 561-570.
Unger et al. (1985) Diabetologia 28:119-121.
Oldendorf et al. (1983) Stroke (14) 388-393.
Winget et al. (1969) Biochemistry (8) 2067-2074.
Vick et al. (1973) Am. Journal of Physiology 224(3) 552-557.
D. Diedrich (1966) Ar. of Biochem. and Biophy. 117: 248-256.
Evans et al. (1980) Ar of Biochem. and Biophy. 199(2)342-348.
Bode et al. (1972) Biochem. Biophys. Acta, 290 134-149.
Arakawa Kenji
Funami Nobuyuki
Hongu Mitsuya
Inamasu Masanori
Tsujihara Kenji
Lee Howard C.
Robinson Douglas W.
Tanabe Seiyaku Co. Ltd.
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