Dihydrocaffeic acid derivatives and pharmaceutical preparations

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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5442375, 544171, 544173, 544174, 544175, 544176, C07D29510

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active

051169797

ABSTRACT:
Dihydrocaffeic acid derivatives are here disclosed which are applicable as medicines having excellent absorbency in the case of oral administration and good concentration retention in blood.
The disclosed compounds have the function to induce the production and secretion of a nerve growth factor (NGF) in the brain tissue, and therefore they are effective as medicines for the progression inhibition and therapy of regressive disorders of the central nervous system.

REFERENCES:
patent: 4053509 (1977-11-01), Faro et al.
patent: 4529604 (1985-07-01), Kaiser
Organic Synthesis, Coll. vol. 3, pp. 575-576, John Wiley & Sons.
Fiat Final Report No. 1313, p. 222 (1948).

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