Dihydrobenzofuran derivatives and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S424000, C549S425000, C549S467000

Reexamination Certificate

active

11409479

ABSTRACT:
Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors.or pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3, R4, Rx, Ry, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.

REFERENCES:
patent: 2554736 (1951-11-01), Haefliger et al.
patent: 3912743 (1975-10-01), Christensen et al.
patent: 4007196 (1977-02-01), Christensen et al.
patent: 4085225 (1978-04-01), Welle et al.
patent: 4136193 (1979-01-01), Bogeso et al.
patent: 4210754 (1980-07-01), Burkard et al.
patent: 4229449 (1980-10-01), Melloni et al.
patent: 4314081 (1982-02-01), Molloy et al.
patent: 4478836 (1984-10-01), Mouzin et al.
patent: 4535186 (1985-08-01), Husbands et al.
patent: 4536518 (1985-08-01), Welch et al.
patent: RE34712 (1994-08-01), Boegesoe et al.
patent: 5384330 (1995-01-01), Dieter et al.
patent: 5565483 (1996-10-01), Hewawasam et al.
patent: 5668145 (1997-09-01), Bright
patent: 5705646 (1998-01-01), Bright et al.
patent: 5712303 (1998-01-01), Faraci et al.
patent: 5916923 (1999-06-01), Rudolph et al.
patent: 6090803 (2000-07-01), Failli et al.
patent: 6096735 (2000-08-01), Ogawa et al.
patent: 6096736 (2000-08-01), Ogawa et al.
patent: 6194407 (2001-02-01), Failli et al.
patent: 6218397 (2001-04-01), Chen
patent: 6274171 (2001-08-01), Sherman et al.
patent: 6403120 (2002-06-01), Sherman et al.
patent: 6419958 (2002-07-01), Sherman et al.
patent: 6444708 (2002-09-01), Rudolph et al.
patent: 6765008 (2004-07-01), Chen
patent: 7045545 (2006-05-01), Briner et al.
patent: 2002/0183395 (2002-12-01), Argentieri et al.
patent: 2004/0029949 (2004-02-01), Argentieri et al.
patent: 2004/0235856 (2004-11-01), McMurray et al.
patent: 2005/0124692 (2005-06-01), Gross et al.
patent: 2005/0143452 (2005-06-01), Gross et al.
patent: 2005/0261347 (2005-11-01), Gross et al.
patent: 2006/0089405 (2006-04-01), Zhou
patent: 2006/0111438 (2006-05-01), Gontcharov et al.
patent: 2006/0241172 (2006-10-01), Zhou et al.
patent: 2006/0241176 (2006-10-01), Stack et al.
patent: 2006/0246551 (2006-11-01), Stack et al.
patent: 2006/0247276 (2006-11-01), Gross et al.
patent: 2006/0252825 (2006-11-01), Tadayon et al.
patent: 2006/0258639 (2006-11-01), Logue et al.
patent: 2006/0258711 (2006-11-01), Rosenzweig-Lipson
patent: 2006/0258712 (2006-11-01), Jacobson
patent: 2006/0258713 (2006-11-01), Rosenzweig-Lipson
patent: 2006/0258714 (2006-11-01), Heffernan et al.
patent: 2006/0258715 (2006-11-01), Jandura et al.
patent: 2006/0258739 (2006-11-01), Ai et al.
patent: WO 2006/000902 (2006-05-01), None
U.S. Appl. No. 11/787,929, Yu et al.
U.S. Appl. No. 11/787,860, Gontcharov et al.
U.S. Appl. No. 11/726.941, Rosenzweig-Lipson.
Allison, et al.,Am. J. Psychiatry, 156: 1686-96, 1999.
Battegay, et al.,Neuropsychobiology, 13:31, 1985.
Bishop, et al.,Expert Opin. Ther. Patent, 13: 1691-1705, 2003.
Bundgaard (ed),Design of Prodrugs, Elsevier, Ch. 1(p. 1-92), Ch.4(p. 157-176), Ch.5(p. 177-198), and Ch.6(199-241),1985.
Bundgaard, et al.,Journal of Drug Delivery Reviews, 8: 1-38, 1992.
Bundgaard,J. of Pharmaceutical Sciences, 77: 285-298, 1988.
Christensen, et al.,Eur. J. Pharmacol., 41: 153, 1977.
Cowen, et al.,Human Psychopharmacology, 10: 385-91, 1995.
Di Giovanni, et al.,Synapse, 35: 53-61, 2000.
Di Matteo, et al.,Neuropharmacology, 37: 265-272, 1998.
Di Matteo, et al.,Neuropharmacology, 38: 1195-1205, 1999.
Dufour, et al.,Int. Clin. Psychopharmacol., 2: 225, 1987.
Fox, et al.,Experimental Neurology, 151: 35-49, 1998.
Hassan, et al.,Brit J. Clin. Pharmacol, 19: 705, 1985.
Lassen,Eur. J. Pharmacol, 47: 351, 1978.
Laursen, et al.,Acta Psychiat. Scand. 71: 249, 1985.
Lowry, et al.,J. Biol. Chem., 193: 265, 1951.
Masand, “Weight gain associated with psychotropic drugs”,Exp. Opin. Pharmacother. I: 377-89, 2000.
Mendell, et al.,N. Engl. J. Med., 348: 1243-55, 2003.
Millan, et al.,Neuropharmacology, 37: 953-55, 1998.
Moret , et al.,Neuropharmacology, 24: 1211-19, 1985.
Robertson, et al.,J. Med. Chem., 31: 1412, 1988.
Rosenzwieg-Lipson, et al., “Antiobesity-like effects of the selective 5-HT2C agonist way”,ASPET abstract, 2000.
Whitaker,Spectrum Life Sciences Decision Resources, 2: 1-9, 2000.
Wilen, et al.,Tetrahedron, 33: 2725-2736, 1977.
Widder, et al (ed.), Methods in Enzymolgoy,Academic Press, 112:56-67, 1985.
International Search Report PCT/US2006/015192.

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