Dihydrobenzofuran and related compounds useful as anti-inflammat

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514337, 514365, 514370, 514422, 514443, 514444, 514469, 544333, 544405, 546121, 5462811, 5462827, 548128, 548131, 548134, 548143, 548154, 548200, 548214, 548247, 548252, 548203, 5483435, 548198, A61K 31435, A61K 31425, C07D30779, C07D40704

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active

058212507

ABSTRACT:
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;

REFERENCES:
patent: 4670457 (1987-06-01), Doria et al.
patent: 4849428 (1989-07-01), Dobson et al.
M.L. Hammond, Kopa I.E., Zambias R.A., Caldwell C.G. Boger J., Baker, F., Bach T., Luell S., & Macintyre D.E., "1,3 Dihydro-5-benzofuranols as Antioxidant-Based Inhibitors of Leukotriene Biosynthesis", J. Med. Chem., vol. 32 (1989), pp. 1006-1020.
O. deMontellano, Correia, P.R., Correia, M.A.; "Suicidal Destruction of Cytochrome P-450 During Oxidative Drug Metabolism", Ann. Rev. Pharmacol, Toxicol., vol. 23 (1983), pp. 481-503.
J.K. Chakrabarti, Eggleton R.J., Gallagher P.T., Harvey J., Hicks T.A., Kitchen E.A., & Smith C-W.; "5-Acyl-3-Substituted-Benzofuran-2(3H)-Ones as Potential Anti-Inflammatory Agents", J. Med. Chem., vol. 30 (1987), pp. 1663-1668.

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