Dihydrobenzofuran- and chroman-carboxamide derivatives, processe

Details Dihydrobenzofuran- and chroman-carboxamide derivatives, processe Dihydrobenzofuran- and chroman-carboxamide derivatives, processe

1987-01-30

1991-04-09

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548525, A61K 3140, C07D40500

Patent

active

050065700

ABSTRACT:
The invention relates to new dihydrobenzofuran- and chroman-carboxamide derivatives of the general formula: ##STR1## in which R and R' are each hydrogen or methyl; n is 1 or 2; m is 1 or 2; Z is either ##STR2## wherein R.sub.1 and R.sub.2 are lower alkyl, or ##STR3## wherein R.sub.3 is alkyl, alkenyl, cycloalkyl-alkyl, cycloalkenyl-alkyl, X is H, NH.sub.2, methoxy, or methyl and Y is H, Cl, cycloalkylmethylsulfonyl, alkylsulfamoyl or alkylsulfonyl
and to their pharmacologically acceptable acid addition salts and their optical isomers, to the processes for the preparation thereof and to the use thereof as medicaments, especially as neuroleptics.

REFERENCES:
patent: 4617314 (1986-10-01), Tahara et al.
patent: 4829067 (1989-05-01), Iijima et al.
Florvall et al., "Annulated Benzamide Deriv.", Chemical Abs., vol. 107(7), No. 58841u (1987).
Sun et al., "Method for Controlling Emesis", Chemical Abs. 1, vol. 110 (11), No. 88631e (1989).

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