Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-05-08
1998-05-05
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514372, 514380, 514384, 514398, 514404, 548213, 548243, 5482646, 5483255, 5483661, 5483644, A61K 3141, A61K 3142, A61K 31415, A61K 31425
Patent
active
057475164
DESCRIPTION:
BRIEF SUMMARY
This application is the national filing under 35 USC 371 of International Application No. PCT/US94/09525 filed Aug. 30, 1994, and is a continuation-in-part of U.S. patent application Ser. No. 08/155,970 filed Nov. 19, 1993 and U.S. patent application Ser. No. 08/155,963 filed Nov. 19, 1993.
BACKGROUND OF THE INVENTION
This invention relates to cyclic amides substituted at the .alpha.-position with various aryl groups, their agriculturally suitable salts and compositions, and methods of their use as general or selective fungicides.
EP-A-398,692 discloses amides of Formula i as fungicides for crop protection. ##STR2## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alky, or lower cycloalkyl. an acyclic alkoxyiminoacetamide group. The cyclic amides of the present invention are not disclosed therein. protection. Compounds of Formula ii are: ##STR3## wherein: W is ##STR4##
Once again, the cyclic amides of this invention are not disclosed therein. J. Heterocyclic Chem., (1987), 24, 465, J. Heterocyclic Chem., (1988), 25, 1307, and Australian J. Chem., (1977), 30 (8), 1815 disclose 4-nitrophenyl isoxazoles (iii), phenyl pyrazolones (iv), and aryl isothiazolinones (v) respectively. ##STR5##
However, no utility as fungicides is alleged and no ortho-substituted compounds of the present invention are disclosed.
SUMMARY OF THE INVENTION
This invention comprises compounds of Formula I including all geometric and stereoisomers, agriculturally suitable salts thereof, agricultural compositions containing them and their use as fungicides: ##STR6## wherein: A is O; S; N; NR.sup.5 ; or CR.sup.14 ; floating double bond is attached to G; and when G is N, A is N or CR.sup.14 and the floating double bond is attached to A; alkyl; C.sub.1 -C.sub.6 haloalkyl; C.sub.2 -C.sub.6 alkenyl; C.sub.2 -C.sub.6 haloalkenyl; C.sub.2 -C.sub.6 alkynyl; C.sub.2 -C.sub.6 haloalkynyl; C.sub.3 -C.sub.6 cycloalkyl; C.sub.2 -C.sub.4 alkylcarbonyl, C.sub.2 -C.sub.4 alkoxycarbonyl; or benzoyl optionally substituted with R.sup.13 ; C.sub.1 -C.sub.6 alkyl; C.sub.1 -C.sub.6 haloalkyl; C.sub.2 -C.sub.6 alkenyl; C.sub.2 -C.sub.6 haloalkenyl; C.sub.2 -C.sub.6 alkynyl; C.sub.2 -C.sub.6 haloalkynyl; C.sub.1 -C.sub.6 alkoxy; C.sub.1 -C.sub.6 haloalkoxy; C.sub.2 -C.sub.6 alkenyloxy; or C.sub.2 -C.sub.6 alkynyloxy; .dbd.CR.sup.6 --; --C.tbd.C--; --CHR.sup.6 O--; --OCHR.sup.6 --; --CHR.sup.6 S(O).sub.n --; --S(O).sub.n CHR.sup.6 --; --CHR.sup.6 O--N.dbd.C(R.sup.7)--; --(R.sup.7)C.dbd.N--OCH(R.sup.6)--; --C(R.sup.7).dbd.N--O--; --O--N.dbd.C(R.sup.7)--; --CHR.sup.6 OC(.dbd.O)N(R.sup.15)--; or a direct bond; and the directionality of the Y linkage is defmed such that the moiety depicted on the left side of the linkage is bonded to the phenyl ring and the moiety on the right side of the linkage is bonded to Z; -C.sub.6 alkoxy; C.sub.1 -C.sub.6 haloalkoxy; C.sub.2 -C.sub.6 alkenyl; C.sub.2 -C.sub.6 haloalkenyl; C.sub.2 -C.sub.6 alkynyl; C.sub.2 -C.sub.6 haloalkynyl; C.sub.3 -C.sub.6 cycloalkyl; C.sub.2 -C.sub.4 alkylcarbonyl; C.sub.2 -C.sub.4 alkoxycarbonyl; cyano; or morpholinyl; -C.sub.10 alkynyl each optionally substituted with R.sup.8 ; or Z is C.sub.3 -C.sub.8 cycloalkyl or phenyl each optionally substituted with one of R.sup.9, R.sup.10, or both R.sup.9 and R.sup.10 ; or Z is a 3 to 14-membered nonaromatic heterocyclic ring system selected from the group monocyclic ring, fused bicyclic ring and fused tricyclic ring, or Z is a 5 to 14-membered aromatic heterocyclic ring system selected from the group monocyclic ring, fused bicyclic ring and fused tricyclic ring, each nonaromatic or aromatic ring system containing 1 to 6 heteroatoms independently selected from the group 1-4 nitrogen, 1-2 oxygen, and 1-2 sulfur, each nonaromatic or aromatic ring system optionally substituted with one of R.sup.9, R.sup.10, or both R.sup.9 and R.sup.10 ; or CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2, CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2, each CH.sub.2 group optionally substituted with 1-2 halogen; or ##STR7## R.sup.3, Y, and Z are taken together with the phenyl ring to form a naph
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Brown Richard James
Frasier Deborah Ann
Sun King-Mo
E. I. Du Pont de Nemours and Company
Gupta Yogendra N.
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