Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-04-15
1997-01-21
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483605, A61K 31415, C07D48704
Patent
active
055960138
ABSTRACT:
The compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof; wherein X.sub.1, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, are inhibitors of PDE IV and the production of tumor necrosis factor. As such, they are active in the treatment of inflammatory diseases, shock etc.
REFERENCES:
Nakano et al, Chemical Abstracts, vol. 121, No. 157661f (1994).
Elguero et al, Chemical Abstracts, vol. 75, 48974 (1971).
Ginsburg Paul H.
Holtrust Gezina
Pfizer Inc
Ramsuer Robert W.
Richardson Peter C.
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