Dihydorbenzofuran and related compounds useful as anti-inflammat

Details Dihydorbenzofuran and related compounds useful as anti-inflammat Dihydorbenzofuran and related compounds useful as anti-inflammat

1995-06-07

1997-11-04

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142335, 514320, 514462, 514469, 544153, 544376, 544 62, 546196, 546316, 548200, 548525, 549345, 549462, 549 57, A61K 3134, C07D30779

Patent

active

056840020

ABSTRACT:
A compound having the structure: ##STR1## wherein (a) W is --C(X')--NRR' or --NR--C(X')R';

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Chakrabarti, J.K., R.J. Eggleton, P.T. Gallagher, J. Harvey, T.A. Hicks, E.A. Kitchen and C. W. Smith, "5-Acyl-3-substituted-benzofuran-2(3H)-ones as Potential Antiinflammatory Agents", J. Med. Chem., vol. 30 (1987), pp. 1663-1668.
Hammond, M.L., I.E. Kopka, R.A. Zambias, C.G. Caldwell, J. Boger, F. Baker, T. Bach, S. Luell and D.E. MacIntyre, "2,3-Dihydro-5-benzofuranols as Antioxidant-based Inhibitors of Leukotriene Biosynthesis", J. Med. Chem., vol. 32 (1989), pp. 1006-1020.
Ortiz de Montelland, P.R. and M.A. Correia, "Suicidal Destruction of Cytochrome P-450 During Oxidative Drug Metabolism", Ann. Rev. Pharmacol. Toxicol., vol. 23 (1983), pp. 481-503.
U.S. application No. 08/280,892, M. W. Scherz, filed Jul. 27, 1994.

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