Dihaloisocyanide derivatives of polymers for coupling nucleophil

Details Dihaloisocyanide derivatives of polymers for coupling nucleophil Dihaloisocyanide derivatives of polymers for coupling nucleophil

1978-06-30

1984-04-03

Naff, David M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

2605432, 435180, 435181, 525921, 528259, 528332, 564148, C12N 1108, C12N 1106, C07G 700, C07C14300

Patent

active

044409036

ABSTRACT:
The present invention relates to novel key intermediates for the production of biologically active compounds coupled to polymers, of the general formula P--NCX.sub.2, wherein X designates a halogen atom selected from chlorine and bromine, and wherein P designates the polymer backbone of a polymer of the polyamide, polyester and ureaformaldehyde type. The invention further relates to compounds obtained by the reaction of the above compound P--NCX.sub.2 with a bifunctional or polyfunctional nucleophile. Suitable nucleophiles are hydrazides of dicarboxylic acids and amongst these there may be mentioned polyacrylamides partially substituted with acylhydrazide groups; polyfunctional amines selected from alkylamines, aralkylamines, arylamines and macromolecular compounds containing amino groups. The key intermediate PNCX.sub.2 may be coupled directly to biologically active macromolecules and amongst the preferred compounds of this type there are the various biologically active proteins and enzymes. The coupling of the biologically active macromolecules may also be effected via hydrophilic polymer moieties first grafted onto the polymer P via said dihaloisocyanide groups.

REFERENCES:
patent: 3619371 (1971-11-01), Crook et al.
patent: 3933589 (1976-01-01), Keyes
patent: 3970597 (1976-07-01), Sokolovsky et al.
patent: 4034139 (1977-07-01), Mazarguil et al.
patent: 4071409 (1978-01-01), Messing et al.
patent: 4098645 (1978-07-01), Hartdegen et al.
patent: 4115305 (1978-09-01), Hornby et al.
patent: 4115305 (1978-09-01), Hornby et al.
Kuehle et al., "New Methods . . . ; Syntheses of Isocyanide Dihalides", Angew. Chem. Internat. Edit., vol. 6, #8, 1967, pp. 649-665.
Kuehle, E., "New Methods . . . ; Reactions of Isocyanide Dihalides and their Derivatives", Angew. Chem. Internat. Edit., vol. 8, #1, 1969, pp. 20-34.
Sundaram et al., Preparation and Properties of Vlease Chemically Attached to Nylon Tube, FEBS Letters, vol. 10, No. 5, 1970, (pp. 325-327).
Goldstein et al., Chemically Modified Nylons as Supports for Enzyme Immobilization, Biochem. J., vol. 143, 1974, (pp. 497-509).
Zabarsky, O., Immobilized Enzymes CRC Press, Cleveland, Ohio, 1973, (pp. 10-20).
Axen et al., The Use of Isocyanides for the Attachment of Biologically Active Substances to Polymers, ACTA Chemice Scandinavica, vol. 25, 1971, (pp. 1129-1169).
Singer, S. J., Preparation of an Electron-Device Antibody Conjugate, Nature, vol. 183, 1959, (pp. 1523-1524).
Day et al., Organic Chemistry. D van Nostrand Co., Inc., N.Y., 1960, (pp. 742, 746 & 747).
Goldstein et al., Chemically Modified Polymers Containing Isocyanide Functional Groups as Supports for Enzyme Immobilization, Biotechnological Applications of Proteins and Enzymes, Academic Press, N.Y., 1977, (pp. 153-167).
Ulrich et al., Syntheses and Reactions of Isocyanide Dihalides, The Chemistry of Cyanates and their Thio Derivatives, part 2, John Wiley & Sons, N.Y., 1977, (pp. 969-1001).

Affiliated with

Also associated with

Rating

Dihaloisocyanide derivatives of polymers for coupling nucleophil does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dihaloisocyanide derivatives of polymers for coupling nucleophil, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dihaloisocyanide derivatives of polymers for coupling nucleophil will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-668016