Dihalocephalomannine and methods of use therefor

Details Dihalocephalomannine and methods of use therefor Dihalocephalomannine and methods of use therefor

1995-12-13

1998-11-24

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549510, 549511, A61K 31335, C07D30514

Patent

active

058407480

ABSTRACT:
Provided are antineoplastic derivatives by a process of selective halogenation of side chains of unsaturated taxanes; more particularly, the process involves the use of halogens, particularly bromine, which is easily added to the side chain double bond of cephalomannine, leaving paclitaxel unchanged, and wherein diastereomeric mixtures of 2", 3"-dibromocephalomannine display high activity against: Leukemia cell line HL-60 (TB); Non-Small Cell Lung Cancer line NCI-H522; Colon Cancer cell lines COLO 205 and HT 29; CNS Cancer cell lines SF-539 and SNB-75; Ovarian Cancer Cell line OVCAR-3; Renal Cancer cell line RXF-393; and Breast Cancer cell lines MCF7, MDA-MB-231/ATCC, HS 578T, MDA-MB-435 and MDA-N.

REFERENCES:
patent: 4814470 (1989-03-01), Colin et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5015744 (1991-05-01), Holton
patent: 5019504 (1991-05-01), Christen et al.
patent: 5059699 (1991-10-01), Kingston et al.
patent: 5136060 (1992-08-01), Holton
patent: 5157049 (1992-10-01), Haugwitz et al.
patent: 5175315 (1992-12-01), Holton
patent: 5194635 (1993-03-01), Kingston et al.
patent: 5200534 (1993-04-01), Rao
patent: 5202448 (1993-04-01), Carver et al.
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5248796 (1993-09-01), Chen et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5250722 (1993-10-01), Bombardelli et al.
patent: 5254580 (1993-10-01), Chen et al.
patent: 5254703 (1993-10-01), Holton
patent: 5272171 (1993-12-01), Ueda et al.
patent: 5274124 (1993-02-01), Holton
patent: 5278324 (1994-01-01), Kingston et al.
patent: 5279949 (1994-01-01), Nair
patent: 5283253 (1994-02-01), Holton et al.
patent: 5284864 (1994-02-01), Holton et al.
patent: 5284865 (1994-02-01), Holton et al.
patent: 5294637 (1994-03-01), Chen et al.
patent: 5296506 (1994-03-01), Kingston et al.
patent: 5300638 (1994-04-01), Farina et al.
patent: 5310672 (1994-05-01), Wann et al.
patent: 5319112 (1994-06-01), Kingston et al.
patent: 5334732 (1994-08-01), Murray et al.
patent: 5336684 (1994-08-01), Murray et al.
patent: 5336785 (1994-08-01), Holton
patent: 5338872 (1994-08-01), Holton et al.
patent: 5412092 (1995-05-01), Rey et al.
patent: 5470766 (1995-11-01), Kingston et al.
patent: 5473055 (1995-12-01), Mongelli et al.
patent: 5475011 (1995-12-01), Ojima et al.
patent: 5475120 (1995-12-01), Rao
"Cephalomannine; a New Antitumor Alkaloid from Cephalotaxus mannii" by Powell et al., J.C.S. Chem. Comm., pp. 102-105 (1979).
"Biologically Active Taxol Anolgues With Depleted A-Ring Side Chain Substituents and Variable C-2' Configurations" by Swindell et al., J.Med.Chem 34 (37:1176-1184 (1991)).

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