Digitalis-like compounds

Details Digitalis-like compounds Digitalis-like compounds

1996-09-12

1999-02-23

Saucier, Sandra E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514 21, 514 34, 540 72, 536 5, 424520, A01N 4500, A01N 4304, A61K 3800, A61K 3512

Patent

active

058744231

ABSTRACT:
A human cataractous lens nuclei methanolic extract characterized in that it comprises substances having a molecular weight lower than 3000 daltons, inhibiting ATP hydrolysis by Na.sup.+,K.sup.+ -ATPase having affinity to the ouabain binding site on the enzyme and cross-reacting with an antibody directed against digoxin. Compounds of the general formula are disclosed: ##STR1## or of the general formula: ##STR2## in which R is hydrogen, an amino acid, a di- or tripeptide or a mono-, di- or trisaccharide. Pharmaceutical preparations and methods of using the compounds are also disclosed.

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