Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2005-12-13
2005-12-13
Casler, Brian L. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S410000, C600S411000, C600S416000, C600S425000, C378S021000, C378S023000, C378S027000, C378S046000, C378S047000, C378S062000, C378S004000, C382S128000, C382S131000, C382S132000
Reexamination Certificate
active
06975894
ABSTRACT:
The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliable and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.
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Gomberg Bryon Roos
Saha Punam K.
Wehrli Felix W.
Casler Brian L.
Drinker Biddle & Reath
Jung William C
McConathy Evelyn R.
Trustees of the University of Pennsylvania
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