Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-07-23
1978-05-30
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26023955C, 2603973, 2603974, 26039745, 26039747, 2603975, C07J 1700
Patent
active
040923100
ABSTRACT:
A novel group of 18,18-difluorosteroids of the general formula ##STR1## wherein St, R.sub.1 and R.sub.2 have the meanings given hereinafter is produced by a chemically novel process characterized in that a corresponding 18-oxo compound is treated with a compound of the formula F.sub.3 SX, wherein X denotes a fluorine atom or an amino group derived from a secondary amine. The compounds of the invention are useful as pharmaceutical intermediates. A number of them are physiologically active and possess hormone-like properties, e.g. those of sexual and/or adrenocortical hormones, such as the gonadotropin-blocking, ovulation-blocking, androgenic, oestrogenic, progestagenic, anabolic, antioestrogenic, antiandrogenic, mineralocorticoid, glucocorticoid and antiinflammatory activity, and can be used in lieu of known hormones or agents possessing corresponding hormone-like properties.
REFERENCES:
patent: 3318922 (1967-05-01), Windholz et al.
patent: 3914265 (1975-10-01), Middleton
"Steroid Reactions" by Dyerassi, (1963), pp. 171-173.
Hasek et al., "Journ. American Chem. Soc.", vol. 82, (1960), pp. 543-548.
Biollaz Michel
Kalvoda Jaroslav
Ciba-Geigy Corporation
Groeger Theodor O.
Roberts Elbert L.
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