Difluoroglutamic acid conjugates with folates and anti-folates f

Details Difluoroglutamic acid conjugates with folates and anti-folates f Difluoroglutamic acid conjugates with folates and anti-folates f

1990-04-12

1991-11-19

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562449, 562573, C07C22924

Patent

active

050668285

ABSTRACT:
This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.

REFERENCES:
patent: 4769389 (1988-09-01), Makovec et al.
D. J. Cichowicz et al., Bio. Chem. 26, pp. 513-521, (1987).
J. J. McGuire et al., J. Biol. Chem. 260, pp. 6747-6754 (1985).
Bio. Chem. Pharm. 34, pp. 2995-2997 (1985).
N. J. Licato, et al., J. Med. Chem., pp. 1022-1027 (1990).
Hogiman et al., Chem. Abst., vol. 87, #177664s, (1978).
McGuire et al., J. Biol. Chem., vol. 260, pp. 6747 (1985).

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