Difluoroglutamic acid conjugates with folates and anti-folates f

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514258, 514259, 514260, 544258, 544259, 544260, 544279, 544287, 544291, 544292, A61K 31505

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active

052867269

ABSTRACT:
This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.

REFERENCES:
patent: 2520392 (1951-10-01), Seeger
patent: 4369319 (1983-01-01), DeGraw
patent: 4460591 (1984-07-01), DeGraw et al.
patent: 4564616 (1986-01-01), Jones et al.
patent: 4584375 (1986-04-01), Coward
patent: 4628089 (1986-12-01), Temple et al.
patent: 4628090 (1986-11-01), Coward
patent: 4853221 (1989-08-01), Elslager et al.
patent: 4882333 (1989-11-01), Shih et al.
patent: 4985441 (1991-01-01), Hughes
patent: 4992550 (1991-02-01), Hughes
patent: 4996207 (1991-02-01), Nair
patent: 5026851 (1991-06-01), Taylor et al.
patent: 5066828 (1991-11-01), Bey et al.
patent: 5167963 (1992-12-01), DeGraw et al.
patent: 5223620 (1993-06-01), Nomura et al.
patent: 5236927 (1993-08-01), Jones et al.
"Freedom of Information Act--Appendix", Hearings before the Subcomm. on Constitution, Senate Fed. Com., 97 Congress, First Session, vol. II, Serial J-97-50, p. 642 (1981).
"DL-3,3-Difluoroglutamate: An Enhancer of Folylpolyglutamate Elongation", McGuire et al., J. Biol. Chem., vol. 265 pp. 14073-14079 (Sep. 1990).
Burger, Medicinal Chemistry, Second Edition, Interscience Publishers, Inc., New York, pp. 78 & 79 (1960).
".gamma.-Fluoromethotrexate: Synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-.gamma.-glutamates", Galivan et al., Proc. Natl. Acad. Sci., May 1985, vol. 82, pp. 2598-2602.
"D,L-3,3-difluoroglutamic acid enhances chain elongation by rat liver folylpolyglutamate synthetase", McGuire et al., Proceedings of the American Association for Cancer Research, vol. 31, Mar. 1990, p. 338, Abstract 2003.

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