Diflunisal esters and related compounds

Details Diflunisal esters and related compounds Diflunisal esters and related compounds

2005-06-21

2005-06-21

Killos, Paul J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C514S533000

Reexamination Certificate

active

06909012

ABSTRACT:
O-medium alkyl esters of diflunisal and related compounds are disclosed having anti-platelet activity, hydroxy radical scavenging properties, enhanced hepatic clearance and low ulcerogenic potential. These compounds have general formula (I) wherein n equals 3-13. 

REFERENCES:
patent: 3674870 (1972-07-01), Ruyle et al.
patent: 3681445 (1972-08-01), Ruyle et al.
patent: 3692821 (1972-09-01), Sarett et al.
patent: 3714226 (1973-01-01), Ruyle et al.
Young et al., “Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A-23187 and lipopolysaccharide stimulation of thromboxane B2 production” Chemical Abstracts, vol. 125 no. 5, issued Jul. 29, 1996 Columbia, Ohio, p. 74 col. 2, abstract 48697j.
Inoue et al., “Comparatiave Study of Human Intestinal and Hepatic Esterases as Related to Enzymatic Properties and Hydrolizing Activity forester-Type Drugs”, Japan J. Pharmacol. 30:529-535 (1980).

Affiliated with

Also associated with

Rating

Diflunisal esters and related compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diflunisal esters and related compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diflunisal esters and related compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3504871