Measuring and testing – Liquid analysis or analysis of the suspension of solids in a... – Osmotic pressure
Patent
1994-04-15
1996-02-13
Williams, Hezron E.
Measuring and testing
Liquid analysis or analysis of the suspension of solids in a...
Osmotic pressure
73 38, 21032184, G01N 1300
Patent
active
054904153
ABSTRACT:
A diffusion test apparatus (2), used to test diffusion of a drug within a vehicle through a test membrane (8), includes a receiver assembly (6) and a donor assembly (4) secured to one another. The receiver assembly includes a number of open-top receiver receptacles (26) arranged in a chosen pattern along its face (12). Similarly, the donor assembly includes a number of open-top donor receptacles (38) arranged along its face (10) in a mirror image of the chosen pattern. The test membrane is captured between the receiver and donor faces. The drug diffuses through the test membrane and into the receiver liquid (53) during an incubation period (62). Samples (66) of the receiver liquid are preferably automatically transferred to a conventional microtiter plate (70) using a programmed liquid transfer system for assay by a scintillation counter (76).
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Francoeur Michael L.
Mak Vivien H. W.
Brock Michael J.
Pharmetrix Corporation
Williams Hezron E.
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